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Cat. No.: HY-181089

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CBX2-IN-1

CBX2-IN-1 is a CBX2 inhibitor with an IC₅₀ of 9.6 μM. CBX2-IN-1 binds the CBX2 chromodomain’s H3K27me3 binding channel, blocks interaction between CBX2 and H3K27me3, and exhibits selective affinity toward CBX2, CBX4, CBX6, CBX7, and CBX8 over CBX1, CBX3, and CBX5. CBX2-IN-1 can be used for the research of prostate cancers.

For research use only. We do not sell to patients.

CAS No.: 3124602-03-2
Formula: C₂₉H₂₇N₃O₃
Molecular Weight:465.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CBX2-IN-1 Chemical Structure

CAS No.: 3124602-03-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

CBX2

9.6 μM (IC₅₀)

All Histone Methyltransferase Isoforms :

In Vitro

CBX2-IN-1 (compound 37) (50 μM) inhibits CBX2 in the NanoBRET assay with an IC₅₀ of 9.6 μM, showing key interactions with the CBX2 chromodomain’s aromatic cage and Asp51 residue^[1].
CBX2-IN-1 likely exhibits selective affinity for CBX2 and closely related isoforms (CBX4, CBX6, CBX7, CBX8) over CBX1, CBX3, and CBX5 due to conserved binding interactions and sequence identity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3124602-03-2
Molecular Weight 465.54
Formula C₂₉H₂₇N₃O₃
SMILES

COC1=CC=CC=C1NC(C2=CC=C(C=C2)NC(CC3=CC=C(C=C3)NCC4=CC=CC=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kawamoto Y, et al. Discovery of novel 4-aminobenzamide derivatives as small molecule CBX2 inhibitors. Bioorg Med Chem Lett. 2026;133:130526. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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