Based on 1 Customer Validation
L-Ascorbic acid (L-Ascorbate) (GMP) is Ascorbic acid (HY-B0166) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Ascorbic acid is an inhibitor of Cav 3.2 channels.
For research use only. We do not sell to patients.
- CAS No.: 50-81-7
- Formula: C6H8O6
- Molecular Weight:176.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: L-ASA
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
| CFPAC-1 | IC50 |
>100 μM
Compound: L-ASA
|
Antiproliferative activity against human CFPAC-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human CFPAC-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
| Erythrocyte | EC50 |
119.87 μg/mL
Compound: Ascorbic acid
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Antioxidant activity in erythrocytes assessed as inhibition of hemolysis
Antioxidant activity in erythrocytes assessed as inhibition of hemolysis
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[PMID: 22677320] |
| Erythrocyte | EC50 |
96.625 μg/mL
Compound: Ascorbic acid
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Hemolysis of human erythrocytes after 30 mins by spectrophotometry
Hemolysis of human erythrocytes after 30 mins by spectrophotometry
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[PMID: 23811092] |
| HCT-116 | IC50 |
>100 μM
Compound: L-ASA
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Antiproliferative activity against human HCT116cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
| HEK293 | EC50 |
0.5 nM
Compound: Ascorbic acid
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Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
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[PMID: 19243956] |
| HEK293 | EC50 |
156 μM
Compound: 54670067
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Substrate uptake and inhibition of the Na(+)/L-Ascorbic Acid Transporter 1 (SVCT1, SLC23A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC23A1 cells (PubChem AID: 1794810)
Substrate uptake and inhibition of the Na(+)/L-Ascorbic Acid Transporter 1 (SVCT1, SLC23A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC23A1 cells (PubChem AID: 1794810)
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10.5281/zenodo.7360349 |
| HeLa | IC50 |
>100 μM
Compound: L-ASA
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
| HepG2 | IC50 |
>100 μM
Compound: L-ASA
|
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
| HFF | IC50 |
>100 μM
Compound: L-ASA
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Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
| HL-60 | IC50 |
0.01 μM
Compound: Vitamin C
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Antioxidant activity in human HL60 cells assessed as inhibition of relative oxygen species generation by DCFH-DA method
Antioxidant activity in human HL60 cells assessed as inhibition of relative oxygen species generation by DCFH-DA method
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[PMID: 19555121] |
| HL-60 | IC50 |
10.2 μM
Compound: Vitamin C
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Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay
Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay
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[PMID: 16562834] |
| HL-60 | IC50 |
9.7 μM
Compound: Vitamin C
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Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay
Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay
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[PMID: 12762791] |
| J774.A1 | IC50 |
>100 μM
Compound: AA
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Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
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[PMID: 33422907] |
| MCF7 | IC50 |
>100 μM
Compound: L-ASA
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
| RD | EC50 |
>2270 μM
Compound: AA
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Antiviral activity against Herpes simplex virus type 1 infected in human RD cells assessed as inhibition of virus-induced cytopathic effect
Antiviral activity against Herpes simplex virus type 1 infected in human RD cells assessed as inhibition of virus-induced cytopathic effect
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[PMID: 22390834] |
| SW-620 | IC50 |
>100 μM
Compound: L-ASA
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Antiproliferative activity against human SW620 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 31586832] |
L-Ascorbic acid (GMP) (25-200 μg/mL) induces chondrogenic differentiation of adipose-derived mesenchymal stem cells[1]. L-Ascorbic acid (GMP) (250 μM; 10 d) induces osteogenic differentiation of mesenchymal stem cells (MSCs)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 50-81-7
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Appearance Solid
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Molecular Weight 176.12
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Formula C6H8O6
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Color White to off-white
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SMILES
OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
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Synonyms
L-Ascorbate (GMP); Vitamin C (GMP)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Barlian A, et al. Chondrogenic differentiation of Wharton's Jelly mesenchymal stem cells on silk spidroin-fibroin mix scaffold supplemented with L-ascorbic acid and platelet rich plasma. Sci Rep. 2020 Nov 10;10(1):19449. [Content Brief]
[2]. Mekala NK, et al. Enhanced proliferation and osteogenic differentiation of human umbilical cord blood stem cells by L-ascorbic acid, in vitro. Curr Stem Cell Res Ther. 2013 Mar;8(2):156-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Ascorbic acid (GMP) Related Classifications
HY-B0166G Related Classifications
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