Cat. No.: HY-124410

Mitoquinol

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs.

For research use only. We do not sell to patients.

Purity: 98.00%
CAS No.: 845959-55-9
Formula: C₃₈H₄₉O₇PS
Molecular Weight:680.83

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Mitoquinol Chemical Structure

CAS No.: 845959-55-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vitro

Mitoquinol (150-500 nM; 30 min-18 h) reduces the oxygen consumption rate associated with ATP production (IC₅₀: 189 nM), increases mitochondrial proton leak, basal oxygen consumption rate, superoxide anion and H₂O₂ production, and enhances glycolysis in bovine aortic endothelial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

Bovine aortic endothelial cells
Concentration:

200 and 300 nM
Incubation Time:

Overnight exposure
Result:

Enhanced superoxide production as demonstrated by fluorescence of the mitochondrial-targeted dihydroethidium probe MitoSOX.

In Vivo

Mitoquinol (40 mg/d; oral administration; twice daily; 3 days) exerts ameliorative effects against heat stress in crossbred barrows^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Crossbred barrows (59.0±5.6 kg) treated acute heat stress^[2]
Dosage:

40 mg/d
Administration:

Oral administration; twice daily; 3 days
Result:

Partially ameliorated the negative effects of acute heat stress on animal performance, inflammation, and metabolism, as evidenced by increased feed intake, attenuated body weight loss, increased blood glucose, and decreased circulating non-esterified fatty acids in heat-stressed pigs compared to heat-stressed controls.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 845959-55-9
Appearance Solid
Molecular Weight 680.83
Formula C₃₈H₄₉O₇PS
Color White to light yellow
SMILES

CC1=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(O)=C(OC)C(OC)=C1O.CS(=O)([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (3)

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Nat Commun

The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis. [Abstract]

2025 Aug 12;16(1):7483. PMID: 40796740
Pharmacol Res

ER stress sensor PERK drives ferroptosis by disrupting MAMs-mediated mitochondrial homeostasis and promoting mtROS accumulation in acute myocardial infarction. [Abstract]

2025 Dec:222:108029. PMID: 41205728
bioRxiv

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. [Abstract]

2025 Oct 30:2025.10.29.685328. PMID: 41279623

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (44.06 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4688 mL

7.3440 mL

14.6880 mL

5 mM

0.2938 mL

1.4688 mL

2.9376 mL

10 mM

0.1469 mL

0.7344 mL

1.4688 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fink BD,et al. Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells. J Pharmacol Exp Ther. 2012 Sep;342(3):709-19. [Content Brief]

[2]. Mayorga EJ, et al. Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows. J Anim Sci. 2024 Jan 3;102:skae161. [Content Brief]

[3]. Pant BD, et al. Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis. J Immunol. 2025 May 12:vkaf078. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4688 mL	7.3440 mL	14.6880 mL	36.7199 mL
	5 mM	0.2938 mL	1.4688 mL	2.9376 mL	7.3440 mL
	10 mM	0.1469 mL	0.7344 mL	1.4688 mL	3.6720 mL
	15 mM	0.0979 mL	0.4896 mL	0.9792 mL	2.4480 mL
	20 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	25 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.4688 mL
	30 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2240 mL
	40 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9180 mL

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Mitoquinol

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Clinical Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Anti-Breast Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Glucose Metabolism Compound Library

Anti-Prostate Cancer Compound Library

Cuproptosis Compound Library

Metabolic Enzyme Compound Library

Macrophage Related Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Anti-Fibrosis Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Mitoquinol

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Mitoquinol Related Classifications

HY-124410 Related Classifications