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Cat. No.: HY-161810

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MRS8247

MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists.

For research use only. We do not sell to patients.

CAS No.: 2991693-72-0
Formula: C₃₃H₄₃N₅
Molecular Weight:509.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MRS8247 Chemical Structure

CAS No.: 2991693-72-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists^[1].

IC₅₀ & Target

A3AR^[1]

All Adenosine Receptor Isoforms :

Chemical Information

CAS No. 2991693-72-0
Molecular Weight 509.73
Formula C₃₃H₄₃N₅
SMILES

NCCCCCCCCC#CC(C=C1)=CC=C1NC2=NC(C=CC=C3)=C3C4=C2N=C(C(CCC)CCC)N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pradhan B, et al. Lipid Trolling to Optimize A3 Adenosine Receptor-Positive Allosteric Modulators (PAMs). J Med Chem. 2024 Jul 25;67(14):12221-12247. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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MRS8247

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MRS8247 Related Classifications

HY-161810 Related Classifications