ROR2
The second member of the ROR family, ROR2, is a Wnt5a receptor with an immunoglobulin-like domain, a frizzled cysteine-rich domain, and a catalytically competent kinase domain followed by serine/threonine-rich and proline-rich tails. Much of its Wnt5a signaling proceeds through kinase-independent, planar cell polarity-type mechanisms. ROR2 is essential for skeletal development: heterozygous dominant mutations cause brachydactyly type B, while biallelic loss-of-function produces Robinow syndrome with limb, vertebral, and facial anomalies. In adults ROR2 is expressed in kidney, lung, and heart, and its reactivation in melanoma, osteosarcoma, and other tumors promotes Wnt5a-driven invasion and metastasis, distinguishing it from the more lymphoid-restricted oncofetal ROR1.
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ROR2 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
