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2-APB

(別名: 2-Aminoethyl diphenylborinate; 2-アミノエチル ジフェニルボリナート)
81 Cited Publications
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Based on 81 publication(s) in Google Scholar

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue.

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  • 純度: 98.86%
  • CAS 番号: 524-95-8
  • 分子式: C14H16BNO
  • 分子量:225.09
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years

    * The compound is unstable in solutions, freshly prepared is recommended.

  • 2-Aminoethyl diphenylborinate Chemical Structure
    2-Aminoethyl diphenylborinate 構造式
  • Experimental Validation Results for 2-Aminoethyl diphenylborinate
  • Experimental Validation Results for 2-Aminoethyl diphenylborinate
  • Experimental Validation Results for 2-Aminoethyl diphenylborinate
  • Experimental Validation Results for 2-Aminoethyl diphenylborinate
  • Experimental Validation Results for 2-Aminoethyl diphenylborinate
  • Experimental Validation Results for 2-Aminoethyl diphenylborinate
CAS 番号: 524-95-8
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MedChemExpress（MCE）の使用を引用している文献 2-Aminoethyl diphenylborinate

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  • 2-Aminoethyl diphenylborinate Chemical Structure
    2-Aminoethyl diphenylborinate Chemical Structure
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    2-Aminoethyl diphenylborinate purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2025 Oct 5;13(10):e012182. [Abstract]

    Customer Validation
     Confocal microscopy analysis of cellular calcium overloading in BMDMs after osimertinib stimulation with or without ML-SI3 (5µM) or 2-APB (10µM; 30 min) pretreatment.

  • 1/16

    2-Aminoethyl diphenylborinate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Nov 10;23(1):1254. [Abstract]

    Customer Validation
     Effect of different calcium ion channel blockers oncell death. HCMEC were pretreated with Dizocilpine (10 µM), Nifedipine (10 µM) and 2-APB (100 µM) for 1 h and then treated with Hcy and CuCl2 underH/R condition for 24 h. Cell death was analyzed by LDH release assay

  • 1/16

    2-Aminoethyl diphenylborinate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Nov 10;23(1):1254. [Abstract]

    Customer Validation
     HCMECs were pretreated with 2-APB (100 µM) for 1 h and then treated with Hcy and CuCl2 under H/R condition for 24 h. Effect of 2-APB on total intracellular and mitochondrial calcium.

  • 1/16

    2-Aminoethyl diphenylborinate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Sep 19;22(1):578. [Abstract]

    Customer Validation
     The effect of 2-APB (0, 25, 50, 100 μM; 2+24 h) on the expression of polarization marker proteins iNOS and Arg-1 in RAW264.7 cells after LPS/IL-4 treatment.

  • 1/16

    2-Aminoethyl diphenylborinate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Nov;8(21):e2101936. [Abstract]

    Customer Validation
     HCT116 cells were pretreated with 2-APB (10 × 10−6 M) for 1 h, followed by SR140333 treatment for 24 h. cell viability was measured by trypan blue exclusion assay.

  • 1/16

    2-Aminoethyl diphenylborinate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Nov;8(21):e2101936. [Abstract]

    Customer Validation
     Western blotting in HCT116 cells treated with SR140333 (38 × 10−6 m) for 24 h after pretreatment with BAPTA-AM (10 ×10−6 M) or 2-APB (10 × 10−6 M) for 1 h.

  • 2-Aminoethyl diphenylborinate