4-MeO-MiPT
4-MeO-MiPT is a serotonin transporter (SERT) inhibitor and serotonin 2A receptor (5-HT2A) agonist with pIC50 and IC50 values of 57 nM and 0.43 nM for human SERT, and pEC50 and EC50 values of 23 nM and 2.3 nM for human 5-HT2A, respectively. 4-MeO-MiPT blocks serotonin uptake via SERT, acts as an agonist at 5-HT2A receptors, and exhibits agonist activity at 5-HT1A, 5-HT1D, 5-HT2B, and 5-HT2C receptors. 4-MeO-MiPT can be used for the research of depression.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 96096-53-6
- 分子式: C15H22N2O
- 分子量:246.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
5-HT2A Receptor 23 nM (EC50) |
5-HT2A Receptor 2.3 nM (pEC50) |
体外実験
4-MeO-MiPT displays nanomolar affinity for multiple serotonin receptor subtypes, SERT, alpha2-adrenergic receptors, and sigma-2 receptors[1].
4-MeO-MiPT is a full agonist at human 5-HT2A receptors and a partial agonist at human 5-HT2B and 5-HT2C receptors, with highest potency at human 5-HT2A and 5-HT2B receptors[1].
4-MeO-MiPT potently inhibits serotonin uptake via SERT in rat brain synaptosomes with an IC50 of 57 nM, and has no meaningful activity at DAT or NET[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male and female, 8 weeks of age)[1]
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Dosage:0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg; 1 mg/kg; 10 mg/kg; 30 mg/kg
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Administration:s.c.; single dose
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Result:Induced a dose-dependent increase in HTR counts, with an ED50 of 0.97 mg/kg and a maximal efficacy of 39 HTRs per 30 minutes.
Increased HTR counts relative to 30 mg/kg 4-MeO-MiPT alone when preceded by 3 mg/kg WAY100635 (HY-10349) pretreatment.
化学情報
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CAS 番号 96096-53-6
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分子量 246.35
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分子式 C15H22N2O
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SMILES
COC1=C2C(CCN(C(C)C)C)=CNC2=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
4-MeO-MiPT 関連分類
HY-W682464 関連分類
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