CaMKII-IN-1
Based on 5 publication(s) in Google Scholar
CaMKII-IN-1 is a highly selective inhibitor of CaMKII with an IC50 value of 63nM. It has almost no effect on CaMKIV, MLCK, p38a, Akt1, and PKC.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.63%
- CAS 番号: 1208123-85-6
- 分子式: C29H30ClN5O2S
- 分子量:548.10
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 CaMKII-IN-1
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生物活性
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CaMK II 63 nM (IC50) |
CaMKII-IN-1 inhibits CaMKII with an IC50 value of 63 nM[1].
CaMKII-IN-1 exhibits more than 100-fold higher selectivity for CaMKII over five types of off-target kinases (CaMKIV, MLCK, p38α, Akt1, PKC)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1208123-85-6
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性状 Solid
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分子量 548.10
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分子式 C29H30ClN5O2S
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Color Light yellow to yellow
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SMILES
O=S(C1=CC=CC(Cl)=C1C)(NC2=C(CN(CC3=CC=CC=C3)CC4)C4=NC(NCCC5=CC=CC=C5)=N2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Feb 7;16(1):1429. PMID: 39920102
CaMKII-IN-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1429. [Abstract]
FACS analysis of CD8+ T-cell proliferation (CFSE low) in cultured with conditioned media derived from MC38 cells treated with WNT11 and inhibitors of CAMKII (CAMKII-IN-1)(100 nM), JNK (JNK-IN-8)(25 nM) and PKC (Go 6983)(100 nM) as indicated.
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Acta Pharmacol Sin
α-MSH-catabolic enzyme prolylcarboxypeptidase in nucleus accumbens shell ameliorates stress susceptibility in mice through regulating synaptic plasticity. [Abstract]2023 Aug;44(8):1576-1588. PMID: 37012493 -
J Ethnopharmacol
Mechanistic insights into Suanzaoren Decoction's improvement of cardiac contractile function in anxiety-induced cardiac insufficiency. [Abstract]2025 Jan 30;337(Pt 2):118860. PMID: 39341264 -
Mol Genet Genomics
CACNA1H restrains chemotherapy resistance in ovarian clear cell carcinoma cells by repressing autophagy. [Abstract]2024 Aug 6;299(1):77. PMID: 39105964 -
Oxid Med Cell Longev
Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm. [Abstract]2021 Dec 21:2021:2502324. PMID: 34970414
溶剤 & 溶解度
DMSO : ≥ 54 mg/mL (98.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8245 mL | 9.1224 mL | 18.2448 mL | 45.6121 mL |
| 5 mM | 0.3649 mL | 1.8245 mL | 3.6490 mL | 9.1224 mL | |
| 10 mM | 0.1824 mL | 0.9122 mL | 1.8245 mL | 4.5612 mL | |
| 15 mM | 0.1216 mL | 0.6082 mL | 1.2163 mL | 3.0408 mL | |
| 20 mM | 0.0912 mL | 0.4561 mL | 0.9122 mL | 2.2806 mL | |
| 25 mM | 0.0730 mL | 0.3649 mL | 0.7298 mL | 1.8245 mL | |
| 30 mM | 0.0608 mL | 0.3041 mL | 0.6082 mL | 1.5204 mL | |
| 40 mM | 0.0456 mL | 0.2281 mL | 0.4561 mL | 1.1403 mL | |
| 50 mM | 0.0365 mL | 0.1824 mL | 0.3649 mL | 0.9122 mL | |
| 60 mM | 0.0304 mL | 0.1520 mL | 0.3041 mL | 0.7602 mL | |
| 80 mM | 0.0228 mL | 0.1140 mL | 0.2281 mL | 0.5702 mL |
CaMKII-IN-1 関連分類
HY-18271 関連分類
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