Estramustine (phosphate sodium)
Based on 1 publication(s) in Google Scholar
Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.
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- 純度: 99.60%
- CAS 番号: 52205-73-9
- 分子式: C23H30Cl2NNa2O6P
- 分子量:564.35
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Estramustine phosphate sodium
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
16 μM
Compound: Estramustine Phosphate Sodium
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Antimitotic activity against human DU-145 cells assessed as reduction in cell proliferation incubated for 72 hrs by alamar blue based fluorescence spectrophotometric analysis
Antimitotic activity against human DU-145 cells assessed as reduction in cell proliferation incubated for 72 hrs by alamar blue based fluorescence spectrophotometric analysis
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[PMID: 37948954] |
Estramustine phosphate sodium (1 µg/ mL, 48 h) suppresses PC3 cell growth[1]. Estramustine phosphate sodium (2 µg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31[1]. Estramustine phosphate sodium (0-40 µM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells[2]. Estramustine phosphate sodium (10 µM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 cells
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Concentration:1 µg/ mL
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Incubation Time:48 h
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Result:Suppressed PC3 cell growth.
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Cell Line:RAW 264.7 cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Disrupted the interphase microtubules.
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Cell Line:18 h of TGF-β treated RAW 264.7 cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Inhibited TGF-β-Induced Cell Migration.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors[3]
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Dosage:4 mg/kg, 12 mg/kg
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Administration:Intraperitoneal injection; daily; for 2 weeks
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Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
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Animal Model:Human prostate cancer xenograft PAC120[3]
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Dosage:4 or 12 mg/kg, a daily dose for 2 weeks.
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Administration:Intraperitoneal injection
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Result:Inhibited PAC120 tumor growth 53% by day 35.
化学情報
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CAS 番号 52205-73-9
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性状 Solid
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分子量 564.35
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分子式 C23H30Cl2NNa2O6P
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Color White to off-white
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SMILES
O=C(N(CCCl)CCCl)OC1=CC2=C(C=C1)[C@@]3([H])CC[C@@]4(C)[C@](CC[C@@H]4OP(O[Na])(O[Na])=O)([H])[C@]3([H])CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
H2O : 62.5 mg/mL (110.75 mM; Need ultrasonic)
DMSO : 5 mg/mL (8.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
[1]. C Wei, et al. Estramustine phosphate induces prostate cancer cell line PC3 apoptosis by down-regulating miR-31 levels. Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):40-45. [Content Brief]
[2]. Sonja S Mojsilovic, et al. Estramustine Phosphate Inhibits TGF- β-Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production. Anal Cell Pathol (Amst). 2018 Sep 2;2018:3134102. [Content Brief]
[3]. Stephane Oudard, et al. Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.7720 mL | 8.8598 mL | 17.7195 mL | 44.2988 mL |
| 5 mM | 0.3544 mL | 1.7720 mL | 3.5439 mL | 8.8598 mL | |
| H2O | 10 mM | 0.1772 mL | 0.8860 mL | 1.7720 mL | 4.4299 mL |
| 15 mM | 0.1181 mL | 0.5907 mL | 1.1813 mL | 2.9533 mL | |
| 20 mM | 0.0886 mL | 0.4430 mL | 0.8860 mL | 2.2149 mL | |
| 25 mM | 0.0709 mL | 0.3544 mL | 0.7088 mL | 1.7720 mL | |
| 30 mM | 0.0591 mL | 0.2953 mL | 0.5907 mL | 1.4766 mL | |
| 40 mM | 0.0443 mL | 0.2215 mL | 0.4430 mL | 1.1075 mL | |
| 50 mM | 0.0354 mL | 0.1772 mL | 0.3544 mL | 0.8860 mL | |
| 60 mM | 0.0295 mL | 0.1477 mL | 0.2953 mL | 0.7383 mL | |
| 80 mM | 0.0221 mL | 0.1107 mL | 0.2215 mL | 0.5537 mL | |
| 100 mM | 0.0177 mL | 0.0886 mL | 0.1772 mL | 0.4430 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Estramustine phosphate sodium 関連分類
HY-13627 関連分類
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