H-Val-Pro-Pro-OH
Based on 1 publication(s) in Google Scholar
H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.77%
- CAS 番号: 58872-39-2
- 分子式: C15H25N3O4
- 分子量:311.38
-
保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
GPCR/G Protein Compound Library
HY-L006
-
Immunology/Inflammation Compound Library
HY-L007
-
Anti-Cardiovascular Disease Compound Library
HY-L046
-
Endocrinology Compound Library
HY-L047
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Glutamine Metabolism Compound Library
HY-L064
-
Angiogenesis-Related Compound Library
HY-L088
-
Peptide Library
HY-L105
-
Anti-Prostate Cancer Compound Library
HY-L124
-
Antihypertensive Compound Library
HY-L145
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Peptide Compound Library
HY-L105S
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
MedChemExpress（MCE）の使用を引用している文献 H-Val-Pro-Pro-OH
MoreAngiotensin Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
IC50: 9 μM (ACE)[1].
H-Val-Pro-Pro-OH, a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM[1]. H-Val-Pro-Pro-OH could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 58872-39-2
-
性状 Solid
-
分子量 311.38
-
分子式 C15H25N3O4
-
Color White to off-white
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Int J Pharm
The search for novel proline analogs for viscosity reduction and stabilization of highly concentrated monoclonal antibody solutions. [Abstract]2024 Apr 25:655:124055. PMID: 38554741
溶剤 & 溶解度
DMSO : 12.5 mg/mL (40.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (278 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. [Content Brief]
[2]. Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2115 mL | 16.0576 mL | 32.1151 mL | 80.2878 mL |
| 5 mM | 0.6423 mL | 3.2115 mL | 6.4230 mL | 16.0576 mL | |
| 10 mM | 0.3212 mL | 1.6058 mL | 3.2115 mL | 8.0288 mL | |
| 15 mM | 0.2141 mL | 1.0705 mL | 2.1410 mL | 5.3525 mL | |
| 20 mM | 0.1606 mL | 0.8029 mL | 1.6058 mL | 4.0144 mL | |
| 25 mM | 0.1285 mL | 0.6423 mL | 1.2846 mL | 3.2115 mL | |
| 30 mM | 0.1071 mL | 0.5353 mL | 1.0705 mL | 2.6763 mL | |
| 40 mM | 0.0803 mL | 0.4014 mL | 0.8029 mL | 2.0072 mL |
Powered by Bioz