Isocitric acid
Based on 2 publication(s) in Google Scholar
Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.14%
- CAS 番号: 320-77-4
- 分子式: C6H8O7
- 分子量:192.12
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Isocitric acid
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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Human Endogenous Metabolite |
体外実験
Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 320-77-4
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性状 Solid
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分子量 192.12
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分子式 C6H8O7
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Color White to off-white
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SMILES
OC(C(O)=O)C(C(O)=O)CC(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Death Dis
m5C-methylated lncRNA NR_033928 promotes gastric cancer proliferation by stabilizing GLS mRNA to promote glutamine metabolism reprogramming. [Abstract]2023 Aug 15;14(8):520. PMID: 37582794
溶剤 & 溶解度
体外:
H2O : 100 mg/mL (520.51 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
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- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720. [Content Brief]
[2]. Tsuruoka M, et al. Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. [Content Brief]
[3]. Zupke C, et al. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.2051 mL | 26.0254 mL | 52.0508 mL | 130.1270 mL |
| 5 mM | 1.0410 mL | 5.2051 mL | 10.4102 mL | 26.0254 mL | |
| 10 mM | 0.5205 mL | 2.6025 mL | 5.2051 mL | 13.0127 mL | |
| 15 mM | 0.3470 mL | 1.7350 mL | 3.4701 mL | 8.6751 mL | |
| 20 mM | 0.2603 mL | 1.3013 mL | 2.6025 mL | 6.5064 mL | |
| 25 mM | 0.2082 mL | 1.0410 mL | 2.0820 mL | 5.2051 mL | |
| 30 mM | 0.1735 mL | 0.8675 mL | 1.7350 mL | 4.3376 mL | |
| 40 mM | 0.1301 mL | 0.6506 mL | 1.3013 mL | 3.2532 mL | |
| 50 mM | 0.1041 mL | 0.5205 mL | 1.0410 mL | 2.6025 mL | |
| 60 mM | 0.0868 mL | 0.4338 mL | 0.8675 mL | 2.1688 mL | |
| 80 mM | 0.0651 mL | 0.3253 mL | 0.6506 mL | 1.6266 mL | |
| 100 mM | 0.0521 mL | 0.2603 mL | 0.5205 mL | 1.3013 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Isocitric acid 関連分類
HY-113228 関連分類
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