MIV-150
MIV-150 is a nonnucleoside reverse transcriptase (NNRT) inhibitor, blocking HIV-1 and HIV-2 infections, with an EC50<1 nM against HIV-1/HIV-2MN.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 231957-54-3
- 分子式: C19H17FN4O3
- 分子量:368.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-10570
NevirapineHIV-1 Reverse Transcriptase Inhibitor -
HY-10574
RilpivirineNNRTI -
HY-90005
Etravirine -
HY-10570R
Nevirapine (Standard)HIV-1 Reverse Transcriptase Inhibitor -
HY-14267
LersivirineNNRTI -
HY-104012
IslatravirNucleoside Reverse Transcriptase Translocation Inhibitor -
HY-90005R
Etravirine (Standard) -
HY-10574R
Rilpivirine (Standard)NNRTI -
HY-104012R
Islatravir (Standard)Reference Standard
生物活性
製品説明
IC50 & Target
[1]|
HIV-1 <1 nM (EC50) |
HIV-2 <1 nM (EC50) |
体外実験
The activity of MIV-150 to protect target cells from infection is assayed using a syncytial assay. The EC50 of MIV-150 against HIV-1MN in CEM.SS cells is below 1 nM. These data are in agreement with the findings of Medivir. MIV-150 effectively inactivated free virus with an EC50 of 0.004 μg/mL (or 0.01 μM). It is demonstrated MIV-150 is highly effective against HIV and that the drug blocks viruses that are resistant to other marketed HIV antiretrovirals such as Nevirapine, Delavirdine, and Efavirenz. In addition, resistance to MIV-150 develops more slowly than to other anti-HIV drugs tested. For example, in vitro studies demonstrate that resistance development in the presence of nevirapine and delavirdine takes only 4 to 5 weeks compared with 45 weeks in the presence of MIV-150[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 231957-54-3
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分子量 368.36
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分子式 C19H17FN4O3
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SMILES
O=C(N[C@@H]1[C@H](C2=C(F)C=CC(C(CC)=O)=C2O)C1)NC3=NC=C(C#N)C=C3
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別名
PC 815
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MIV-150 関連分類
HY-19378 関連分類
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