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Olcegepant

(別名: BIBN-4096; BIBN 4096BS)
47 Cited Publications
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Based on 47 publication(s) in Google Scholar

Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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  • 純度 : 99.07%
  • CAS 番号: 204697-65-4
  • 分子式: C38H47Br2N9O5
  • 分子量:869.65
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Olcegepant Chemical Structure
    Olcegepant 構造式
  • Experimental Validation Results for Olcegepant
  • Experimental Validation Results for Olcegepant
  • Experimental Validation Results for Olcegepant
  • Experimental Validation Results for Olcegepant
  • Experimental Validation Results for Olcegepant
CAS 番号: 204697-65-4
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MedChemExpress（MCE）の使用を引用している文献 Olcegepant

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In Vivo Efficacy StudyFlow CytometryELISAHistological Imaging/Staining
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  • Histological Imaging/Staining
  • Flow Cytometry
  • ELISA
  • In Vivo Efficacy Study

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  • Olcegepant Chemical Structure
    Olcegepant Chemical Structure
    1/16
  • 1/16

    Olcegepant purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(14):e2409251. [Abstract]

    Customer Validation
     Typical micro‐CT images of knee joints on the 28th day after S. aureus infection in vehicle and Olcegepant (BIBN4096, 5 µg/5 µL; intra-articular injection into the knee joint 2 h before infection; once weekly) treated mice (left) and the differences in tibial epiphyseal volume between the two groups (right). n = 5 mice/group. (Scale bar: 500 µm).

  • 1/16

    Olcegepant purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(14):e2409251. [Abstract]

    Customer Validation
     Olcegepant (BIBN4096, 5 µg/5 µL; intra-articular injection into the knee joint 2 h before infection; once weekly).
    Typical H&E-stained images of knee joints (left) and scores based on H&E staining that show differences in synovial and bone damage between the two groups on the 28th day after S. aureus infection (right). n = 8 mice/group (Scale bar: 500 µm).

  • 1/16

    Olcegepant purchased from MedChemExpress. Usage Cited in: Cell. 2024 Jun 6;187(12):2935-2951.e19. [Abstract]

    Customer Validation
     Representative pseudocolor plots (L) and summary data (M) of proportions of splenic GC B cells and SPPCs 13 days after NP-KLH immunization in mice i.p. injected with vehicle or Olcegepant (BIBN4096, 5 mg/kg) every other day. n = 17 mice per group.

  • 1/16

    Olcegepant purchased from MedChemExpress. Usage Cited in: Cell. 2024 Jun 6;187(12):2935-2951.e19. [Abstract]

    Customer Validation
     ELISA titration curves of NP-specific IgG antibodies on day 13 post NP-KLH immunization in mice i.p. injected with vehicle or Olcegepant (BIBN4096, 5 mg/kg) every other day. n = 12 mice per group.

  • 1/16

    Olcegepant purchased from MedChemExpress. Usage Cited in: Nat Med. 2016 Oct;22(10):1160-1169. [Abstract]

    Customer Validation
     In vivo imaging (by IVIS200 system) of different organs in a rat 2 weeks after injections of Cy5‐labeled Olcegepant (BIBN4096BS, BIBN, 750 µg/mL, 100 µL, pH 6.0, every other day) , a CGRP receptor antagonist, into left femur.

  • Olcegepant