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RepSox

(別名: E-616452; SJN 2511)
22 Cited Publications
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Based on 22 publication(s) in Google Scholar

RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.92%
  • CAS 番号: 446859-33-2
  • 分子式: C17H13N5
  • 分子量:287.32
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • RepSox Chemical Structure
    RepSox 構造式
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
  • Experimental Validation Results for RepSox
CAS 番号: 446859-33-2
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MedChemExpress（MCE）の使用を引用している文献 RepSox

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IFWBIn Vivo Efficacy Study2D/3D Cell Culture and DifferentiationRT-PCRFlow CytometryHistological Imaging/Staining
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  • RepSox Chemical Structure
    RepSox Chemical Structure
    1/16
  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     Schemes of generating Fsp1-Cre:R26R-loxp-tdTomato mice and drug treatment to induce in situ transdifferentiation. Fsp1-Cre mice were crossed with R26Rloxp-tdTomato mice in which the expression of tdTomato is prevented by a loxP-flanked STOP cassette. The F1 mice would have the red fluorescent protein tdTomato expressed specifically in the fibroblasts. CRFVPTM were given once a week for 6 weeks. Immunofluorescence staining of the cryosections of the hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with vehicle (b) or CRFVPTM (c) for 6 weeks. C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age.

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     Whole-heart imaging with light-sheet fluorescence microscopy after tissue clearing of the hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with vehicle (a) or CRFVPTM (b). (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     a Schemes of obtaining PDGFRα-DreER:R26R-rox-tdTomato mice and drug treatment to induce in situ cardiac reprogramming in PDGFRα-DreER:R26R-roxtdTomato mice. PDGFRα-DreER mice were mated with R26R-rox-tdTomato mice in which the expression of tdTomato is prevented by a roxflanked STOP cassette. The expression of tdTomato in fibroblasts was turned on by tamoxifen treatment. CRFVPTM were given once a week for 6 weeks. b Body weigh change of the mice after chemical treatment. Immunofluorescence staining of the cryosections of the hearts from PDGFRα-DreER:R26R-rox-tdTomato mice treated with vehicle (c) or CRFVPTM (d) for 6 weeks. (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     Immunofluorescence staining of α-actinin in cryosections of hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with 7 C cocktail (CRFVPTM) or cocktails by removing 1 compound from 7 C (7C-X) for 6 weeks in vivo with Fsp1-Cre:R26R-loxp-tdTomato mice. (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 Apr 14;7(16):eabb2213. [Abstract]

    Customer Validation
     Western blotting of the control hESC and the RCBB (including 5 μM Repsox, 6-8 d)-induced cells.

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2020 Nov 1;7(1):52. [Abstract]

    Customer Validation
     Chemical induction of human lung fetal IMR-90 fibroblasts into neuron-like cells. Representative microscopy images depicting the morphological changes after Repsox (2  μmol/L, 14 d) induction. Scale bars=100 μm.

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Biomaterials. 2018 Dec 6;193:30-46. [Abstract]

    Customer Validation
     Generation of RepSox (10 μM, 6 d) induced skeletal muscle like cells (CiSMLC) from mouse embryonic fibroblasts (MEFs). Immunohistochemical detection of CiSMLC with various skeletal muscle markers: MHC (MF20) and MyoD (Upper panel), α-actinin and its overlap with phase contrast image (middle panel), and Myogenin and its overlap with phase contrast images (lower panel). Magnified images in the inset are used to depict the detailed localization and co-expression and of these markers. All scale bars: 100 μm.

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Biomaterials. 2018 Dec 6;193:30-46. [Abstract]

    Customer Validation
     Generation of RepSox (10 μM, 6 d) induced skeletal muscle like cells (CiSMLC) from mouse embryonic fibroblasts (MEFs). Semi-quantitative RT-PCR analysis of various skeletal specific markers.

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Biomaterials. 2018 Dec 6;193:30-46. [Abstract]

    Customer Validation
     Representative flow cytometry analysis of α-actinin positive cells upon 4-factor (including RepSox 10 μM) treatment for indicated times (6-15 d).

  • 1/16

    RepSox purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jun 19;8(36):60159-60172. [Abstract]

    Customer Validation
     SH-SY5Y (A) and HEK293 cells (B) are treated with 25 μM RepSox (Rep) in absence or presence of dPA or dPPA for 72 h, and the Western blotting results show that dPA or dPPA increases the expression in the presence of RepSox. RepSox does not cause significant alteration of furin protein compared to control. The expression of furin remains significantly increased after dPA or dPPA in the presence of RepSox.

  • RepSox