Antibody-Oligonucleotide Conjugates (AOCs)
Antibody-Oligonucleotide Conjugate (AOC) consists of three parts: antibody, linker and oligonucleotide. AOC combines the tissue-specific targeting of antibody drugs with the target-specific capabilities of small nucleic acids, addressing the limitation of current small nucleic acid drugs that mainly target the liver through LNP and GalNAc delivery systems.
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Antibody-Oligonucleotide Conjugates (AOCs) 関連製品 (10)
関連製品 (10)
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Etedesiran
0 Images製品番号: HY-147262Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1.
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DBCO-PEG4-Val-Cit-PAB-PNP
0 Images製品番号: HY-W190913CAS 番号: 2226472-28-0DBCO-PEG4-Val-Cit-PAB-PNP is a linker. DBCO-PEG4-Val-Cit-PAB-PNP conjugates anti-SYT2 monoclonal antibody with MALAT1 gapmer antisense oligonucleotides without inhibiting ASO activity or impairing the binding efficiency of the antibody to SYT2 antigen.
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Braxlosiran
0 Images製品番号: HY-177971Braxlosiran is a component of the AOC reagent Delpacibart braxlosiran (HY-177566), consisting of an siRNA targeting DUX4 (double homeobox protein) and SMCC linker (HY-42360). Delpacibart braxlosiran binds to TfR1. Aberrant expression of the DUX4 protein causes changes in gene expression in muscle cells, which are associated with muscle function loss in facioscapulohumeral muscular dystrophy (FSHD).
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Zotadirsen
0 Images製品番号: HY-177972Zotadirsen is the core component of the AOC drug Delpacibart zotadirsen (AOC1044) (HY-177564), consisting of a phosphorodiamidate morpholino oligonucleotide (PMO) targeting exon 44 of the dystrophin gene and an SMCC linker (HY-42360). Upon conjugation with the anti-TfR1 antibody Delpacibart (HY-P990051), Zotadirsen exerts splicing regulatory activity and mediates exon skipping. Zotadirsen can be used in studies related to AOC synthesis.
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Zoratolimod scrambled negative control
0 Images製品番号: HY-177973AZoratolimod scrambled negative control is the sequence scrambled negative control of Zoratolimod.
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Braxlosiran scrambled negative control
0 Images製品番号: HY-177971ABraxlosiran scrambled negative control is the sequence scrambled negative control of Braxlosiran.
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Zotadirsen scrambled negative control
0 Images製品番号: HY-177972AZotadirsen scrambled negative control is the sequence scrambled negative control of Zotadirsen.
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Etedesiran scrambled negative control
0 Images製品番号: HY-147262AEtedesiran scrambled negative control is the sequence scrambled negative control of Etedesiran.
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Bis-Mal-Lysine-PEG4-DBCO
0 Images製品番号: HY-186089CAS 番号: 3113277-32-7Bis-Mal-Lysine-PEG4-DBCO (CGBS-13) is a linker for AOC drugs and can be used to synthesize AOC drugs that inhibit DMPK gene expression.
