Tramiprosate
Based on 3 publication(s) in Google Scholar
Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 3687-18-1
- 分子式: C3H9NO3S
- 分子量:139.17
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Tramiprosate
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生物活性
製品説明
体外実験
Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO)[1]
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Dosage:50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg
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Administration:Intraperitoneal injection; once
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Result:Dose-dependently reduced the infarct volume after MCAO.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 3687-18-1
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性状 Solid
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分子量 139.17
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分子式 C3H9NO3S
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Color White to off-white
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SMILES
NCCCS(=O)(O)=O
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別名
Homotaurine; 3-Amino-1-propanesulfonic acid
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Aug 11;16(1):7394. PMID: 40789850 -
J Orthop Translat
Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury. [Abstract]2026 Mar 2:57:101049. PMID: 41808881 -
Drug Dev Res
Tramiprosate, the Active Agent of ALZ-801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease. [Abstract]2026 Jun;87(4):e70330. PMID: 42237659
溶剤 & 溶解度
体外:
H2O : ≥ 100 mg/mL (718.55 mM)
DMSO : 1 mg/mL (7.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 140 mg/mL (1005.96 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (273 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17. [Content Brief]
[2]. Francine Gervais, et al. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28(4):537-47. [Content Brief]
[3]. R G Fariello, et al. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology. 1982 Mar;32(3):241-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 7.1855 mL | 35.9273 mL | 71.8546 mL | 179.6364 mL |
| 5 mM | 1.4371 mL | 7.1855 mL | 14.3709 mL | 35.9273 mL | |
| H2O | 10 mM | 0.7185 mL | 3.5927 mL | 7.1855 mL | 17.9636 mL |
| 15 mM | 0.4790 mL | 2.3952 mL | 4.7903 mL | 11.9758 mL | |
| 20 mM | 0.3593 mL | 1.7964 mL | 3.5927 mL | 8.9818 mL | |
| 25 mM | 0.2874 mL | 1.4371 mL | 2.8742 mL | 7.1855 mL | |
| 30 mM | 0.2395 mL | 1.1976 mL | 2.3952 mL | 5.9879 mL | |
| 40 mM | 0.1796 mL | 0.8982 mL | 1.7964 mL | 4.4909 mL | |
| 50 mM | 0.1437 mL | 0.7185 mL | 1.4371 mL | 3.5927 mL | |
| 60 mM | 0.1198 mL | 0.5988 mL | 1.1976 mL | 2.9939 mL | |
| 80 mM | 0.0898 mL | 0.4491 mL | 0.8982 mL | 2.2455 mL | |
| 100 mM | 0.0719 mL | 0.3593 mL | 0.7185 mL | 1.7964 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tramiprosate 関連分類
HY-14602 関連分類
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