Adenosine dialdehyde
Based on 7 publication(s) in Google Scholar
Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.
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- 純度: 99.0%
- CAS 番号: 34240-05-6
- 分子式: C10H11N5O4
- 分子量:265.23
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Adenosine dialdehyde
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L929 | IC50 |
3.1 μg/mL
Compound: 1
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Compound was tested for antiviral activity against vesicular stomatitis virus (VSV) in L929 cells.
Compound was tested for antiviral activity against vesicular stomatitis virus (VSV) in L929 cells.
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10.1016/0960-894X(96)00234-X |
| Vero | IC50 |
0.41 μg/mL
Compound: 1
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Compound was tested for antiviral activity against vaccinia virus in Vero cells.
Compound was tested for antiviral activity against vaccinia virus in Vero cells.
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10.1016/0960-894X(96)00234-X |
Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 μM with producing 50% inhibition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male A/J mice, weighing 20 to 25 g with MNB cells[3]
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Dosage:1.5-2.5 mg/kg
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Administration:Subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval (minipump infusion)
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Result:Significantly suppressed murine neuroblastoma tumor growth.Prolongs the life span of tumor bearing mice.Did not suppress hematopoiesis when administered by steady state infusion[2].
化学情報
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CAS 番号 34240-05-6
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性状 Solid
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分子量 265.23
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分子式 C10H11N5O4
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Color White to off-white
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SMILES
O=CC(OC(C=O)CO)N1C=NC2=C(N)N=CN=C12
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Adv Mater
2025 May 16:e2420445. PMID: 40376881 -
J Clin Invest
Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase. [Abstract]2025 Jul 22;135(19):e190215. PMID: 40694424 -
Cell Death Differ
Targeting ADAR1 lactylation activates innate immune and overcomes chemoresistance in ovarian cancer. [Abstract]2026 May 25. PMID: 42185630 -
Phytomedicine
Baicalein specifically suppresses microsatellite instability colorectal cancer by targeting adenosylhomocysteinase to inhibit histone H3 lysine 4 trimethylation-mediated cancer stemness. [Abstract]2025 Sep 22:148:157291. PMID: 41038143 -
Cell Rep
Inhibiting UPF1 methylation enhances tumor immunotherapy sensitivity by reducing nonsense-mediated mRNA decay. [Abstract]2025 Jun 25;44(7):115919. PMID: 40570371 -
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溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (377.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. V Ramakrishnan, et al. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells. Neurochem Int. 1987;10(4):423-31. [Content Brief]
[2]. G V Madhavan, et al. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem [Content Brief]
[3]. B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48(21):5933-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7703 mL | 18.8516 mL | 37.7031 mL | 94.2578 mL |
| 5 mM | 0.7541 mL | 3.7703 mL | 7.5406 mL | 18.8516 mL | |
| 10 mM | 0.3770 mL | 1.8852 mL | 3.7703 mL | 9.4258 mL | |
| 15 mM | 0.2514 mL | 1.2568 mL | 2.5135 mL | 6.2839 mL | |
| 20 mM | 0.1885 mL | 0.9426 mL | 1.8852 mL | 4.7129 mL | |
| 25 mM | 0.1508 mL | 0.7541 mL | 1.5081 mL | 3.7703 mL | |
| 30 mM | 0.1257 mL | 0.6284 mL | 1.2568 mL | 3.1419 mL | |
| 40 mM | 0.0943 mL | 0.4713 mL | 0.9426 mL | 2.3564 mL | |
| 50 mM | 0.0754 mL | 0.3770 mL | 0.7541 mL | 1.8852 mL | |
| 60 mM | 0.0628 mL | 0.3142 mL | 0.6284 mL | 1.5710 mL | |
| 80 mM | 0.0471 mL | 0.2356 mL | 0.4713 mL | 1.1782 mL | |
| 100 mM | 0.0377 mL | 0.1885 mL | 0.3770 mL | 0.9426 mL |
Adenosine dialdehyde 関連分類
HY-123055 関連分類
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