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製品番号: HY-184991

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AK305

AK305 is a small-molecule ligand for the SH2 domains of STAT5A, STAT5B and STAT6, with a K_i of 0.4 μM for STAT6 and a K_i of 1.0 μM for both STAT5A and STAT5B. AK305 exhibits only very low or no cell growth inhibitory activity in leukemia cells and does not alter STAT protein levels. AK305 serves as the STAT5 ligand for AK-2292 (HY-148813), a STAT5 PROTAC degrader. AK305 can be used in the research of acute myeloid leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2982853-56-3
分子式: C₃₅H₄₀F₂N₅O₇PS₂
分子量:775.82

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AK305 構造式

CAS 番号: 2982853-56-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

STAT6

0.4 μM (Ki)

STAT5a

1 μM (Ki)

STAT5b

1 μM (Ki)

STAT5

STAT アイソフォーム固有の製品をすべて表示 :

体外実験

AK305 binds with equal affinity to purified STAT5A and STAT5B proteins (K_i = 1.0 μM) and with higher affinity to purified STAT6 protein (K_i = 0.4 μM)^[1].
AK305 (5 μM; 18 h) does not alter the levels of any STAT family proteins in SKNO1 AML cells^[1].
AK305 (5 μM; 6 h) does not alter the levels of any STAT family proteins in MV4;11 AML cells^[1].
AK305 (15 μM; 4 days) does not inhibit cell growth in SKNO1, Kasumi-3, or MV4;11 AML cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SKNO1 acute myeloid leukemia (AML) cells
Concentration:

5 μM
Incubation Time:

18 h
Result:

Exerted no effect on the levels of STAT5A, STAT5B, phosphorylated STAT5 (pSTAT5ᵞ⁶⁹⁴), STAT1, STAT2, STAT3, STAT4, or STAT6 proteins.

Western Blot Analysis^[1]

Cell Line:

MV4;11 acute myeloid leukemia (AML) cells
Concentration:

5 μM
Incubation Time:

6 h
Result:

Exerted no effect on the levels of STAT5, phosphorylated STAT5 (pSTAT5ᵞ⁶⁹⁴), STAT1, STAT2, STAT3, or STAT6 proteins.

化学情報

CAS 番号 2982853-56-3
分子量 775.82
分子式 C₃₅H₄₀F₂N₅O₇PS₂
SMILES

FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N(CCC(N(C)C)=O)C4=CC=C(C5=NC=CS5)C=C4)=O)CCC3)=O)=O)S2)=C1)(P(O)(O)=O)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kaneshige A, et al. Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity in Acute Myeloid Leukemia. Journal of medicinal chemistry. 2023 Feb 23;66(4):2717-2743. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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AK305

STAT アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

AK305 関連分類

HY-184991 関連分類

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Keywords

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