Antazoline phosphate
Antazoline phosphate is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect. Antazoline phosphate is a histamine H1 receptor antagonist with anticholinergic and antiviral properties. Antazoline phosphate can prevent histamine from acting on target cells through a reversible competition effect on histamine receptor sites of these cells. Antazoline phosphate can exert an antiallegic effect and prevent the occurrence of physiological reactions from the effect of blocking as well as inhibiting H1 receptor. Antazoline phosphate can effectively reduce HBV DNA in the extracellular supernatant in a dose-dependent manner, with EC50 of 2.910 μmol/L in HepAD38 cells. Antazoline phosphate also has a significant inhibitory effect on HBV DNA in the extracellular supernatant of Huh7 cells (EC50 = 2.349 μmol/L). Antazoline phosphate has anti-arrhythmic effect in acute myocardial infarctions. Antazoline phosphate can be studied in research for cardiovascular diseases, and HBV.
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- CAS 番号: 154-68-7
- 分子式: C17H22N3O4P
- 分子量:363.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Antazoline phosphate shows good inhibitory effect on HBV DNA in the supernatant of HepAD38 and Huh7 cells with the value of EC50 is 2.910 μmol/L and 2.349 μmol/L, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepAD38 cells
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Concentration:10 μmol/L
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Incubation Time:5 days
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Result:Exhibited no significant cytotoxicity at a concentration of 10μmol/L and had a dose-dependent inhibition of HBV DNA in the supernatant.
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Cell Line:Huh7 cells
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Concentration:30 μmol/L, 10 μmol/L, 3.33 μmol/L, 1.1 μmol/L, 0.370 μmol/L, and 0.123 μmol/L
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Incubation Time:4 days
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Result:Had a significant inhibitory effect on HBV DNA in supernatants in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice[3]
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Dosage:0.01 mL/g
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Administration:IP; 0.01 ml/g; 30min
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Result:Showed some proconvulsive activity.
化学情報
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CAS 番号 154-68-7
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分子量 363.35
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分子式 C17H22N3O4P
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SMILES
O=P(O)(O)O.C1(CN(C2=CC=CC=C2)CC3=CC=CC=C3)=NCCN1
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別名
Phenazoline phosphate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wang, R., et al., (2013). Determination of antazoline hydrochloride in rat plasma and excreta by reversed-phase ion-pair chromatography and its application to pharmacokinetics. Biomedical chromatography : BMC, 27(12), 1595–1602. [Content Brief]
[2]. Li, J., et al., (2021). Repurposing of Antazoline Hydrochloride as an Inhibitor of Hepatitis B Virus DNA Secretion. Virologica Sinica, 36(3), 501–509. [Content Brief]
[3]. Gehring, D. A., & Kehler, J. G. (1970). Conversion of atrial fibrillation with antazoline hydrochloride (Arithmin). Angiology, 21(1), 11–17. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antazoline phosphate 関連分類
HY-B1067B 関連分類
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