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製品番号: HY-154866

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Anticancer agent 122

Anticancer agent 122, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2924532-50-1
分子式: C₁₈H₁₅ClN₂O₂S
分子量:358.84

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

Anticancer agent 122 構造式

CAS 番号: 2924532-50-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Anticancer agent 122, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research^[1].

体外実験

Anticancer agent 122 (Compound 8m) (0-100 μM; 72 hours) inhibits liver cancer cell line HepG2 cells and cervical cancer cell line SiHa cells with IC₅₀s of 5.15 μΜ and 1.65 μΜ，respectively and has not noticeable toxicity in human embryonic kidney cell line HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK293, HepG2 and SiHa
Concentration:

0-100 μM
Incubation Time:

72 hours
Result:

Inhibited liver cancer cell line HepG2 cells and cervical cancer cell line SiHa cells with IC₅₀s of 5.15 μΜ and 1.65 μΜ，respectively.
Had not noticeable toxicity in HEK293.

化学情報

CAS 番号 2924532-50-1
分子量 358.84
分子式 C₁₈H₁₅ClN₂O₂S
SMILES

O=C(OC)C/N=C1SC=C(C2=CC=CC=C2)N/1C3=CC=C(Cl)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (286 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sharma D, et.al.Design and Synthesis of Thiazole Scaffold-Based Small Molecules as Anticancer Agents Targeting the Human Lactate Dehydrogenase A Enzyme. ACS Omega. 2023 May 10;8(20):17552-17562. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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