Apraclonidine
Based on 3 publication(s) in Google Scholar
Apraclonidine (ALO 2145 (free base)), a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 66711-21-5
- 分子式: C9H10Cl2N4
- 分子量:245.11
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Apraclonidine
MoreAdrenergic Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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α adrenergic receptor |
Apraclonidine (ALO 2145 (free base)) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male rabbits[3]
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Dosage:1.15%
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Administration:Apraclonidine (1.15%, single instillation)
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Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 66711-21-5
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分子量 245.11
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分子式 C9H10Cl2N4
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SMILES
NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1
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別名
ALO 2145 free base
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chim Acta
Bifunctional Ti4+-modified paper for selective extraction or removal of phospholipids and paper spray mass spectrometry for bioanalysis in urine and plasma. [Abstract]2023 Oct 16:1278:341673. PMID: 37709425 -
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純度とドキュメンテーション
参考文献
[1]. Subhashie Wijemanne, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci [Content Brief]
[2]. R V Searles, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999 Apr;58(4):220-6. [Content Brief]
[3]. Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apraclonidine 関連分類
HY-12720 関連分類
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