ArMan
ArMan is a co-activator of DC-SIGN (CD209) and TLR7. ArMan can selectively bind to DC-SIGN, promoting receptor-mediated endocytosis of the virus-like particle (VLP) platform, thereby enhancing co-binding with TLR7. ArMan can drive dendritic cell activation, shifting the immune response from humoral immunity to type 1 cellular immunity. ArMan can be used in melanoma research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C19H25NO7
- 分子量:379.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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TLR7 |
ArMan (8 nM; 30 min) displayed by VLPs exhibits enhanced colocalization with DC-SIGN and TLR7 in human monocyte-derived dendritic cells following 30 min of incubation[1].
ArMan (8 nM; 24 h) displayed by VLPs induces robust activation of human monocyte-derived dendritic cells, with significantly increased surface expression of CD40, CD80, CD83, and CD86 after 24 h of incubation, dependent on DC-SIGN binding[1].
ArMan (8 nM; 6 h) displayed by VLPs upregulate TLR7-associated gene expression and hallmark DC activation pathways in human monocyte-derived dendritic cells after 6 h of incubation[1].
ArMan (8 nM; 32 h) displayed by VLPs induce significantly higher secretion of pro-inflammatory cytokines (TNF-α, IL-6, CXCL10, IL-8, IL-12p70) by human monocyte-derived dendritic cells after 32 h of incubation, dependent on DC-SIGN engagement[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ArMan (s.c. or i.p.; days 3, 9, 15) delivered via VLPs functions as a self-adjuvanting cancer vaccine component, inducing robust tumor antigen-specific CD8+ T cell responses and supporting anti-tumor efficacy in mice without the need for additional adjuvants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 379.40
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分子式 C19H25NO7
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SMILES
OC[C@H]([C@H]([C@@H]1O)O)O[C@@H]([C@H]1O)OC2=CC=C(CCNC(CCC#C)=O)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ArMan 関連分類
HY-175421 関連分類
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