製品番号: HY-149464

ARN22089

カスタマーレビュー

Based on 1 Customer Validation

ARN22089 is a oral active novel class of trisubstituted pyrimidine, blocks the interaction of CDC42 GTPases with specific downstream effectors. ARN22089 blocks tumor growth in BRAF mutant mouse melanoma model.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.18%
CAS 番号: 2248691-29-2
分子式: C₂₃H₂₇N₅
分子量:373.49

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ARN22089 構造式

CAS 番号: 2248691-29-2

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Ras アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	4.9 μM Compound: 17; ARN22089	Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay	[PMID: 37026468]
A-375	IC₅₀	4.9 μM Compound: ARN22089	Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SK-MEL-28	IC₅₀	24.8 μM Compound: 17; ARN22089	Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay	[PMID: 37026468]
SK-MEL-28	IC₅₀	24.8 μM Compound: ARN22089	Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SK-MEL3	IC₅₀	4.2 μM Compound: ARN22089	Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]
SW480	IC₅₀	8.6 μM Compound: 17; ARN22089	Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay	[PMID: 37026468]
SW480	IC₅₀	8.6 μM Compound: ARN22089	Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay	[PMID: 38866385]

化学情報

CAS 番号 2248691-29-2
性状 Solid
分子量 373.49
分子式 C₂₃H₂₇N₅
Color Off-white to light yellow
SMILES

CN(C)C1=CC(NC2=CC(C3=CC=CC=C3)=NC(C4CCNCC4)=N2)=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (267.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6774 mL

13.3872 mL

26.7745 mL

5 mM

0.5355 mL

2.6774 mL

5.3549 mL

10 mM

0.2677 mL

1.3387 mL

2.6774 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Brindani N, et al. Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer. J Med Chem. 2023;66(8):5981-6001. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6774 mL	13.3872 mL	26.7745 mL	66.9362 mL
	5 mM	0.5355 mL	2.6774 mL	5.3549 mL	13.3872 mL
	10 mM	0.2677 mL	1.3387 mL	2.6774 mL	6.6936 mL
	15 mM	0.1785 mL	0.8925 mL	1.7850 mL	4.4624 mL
	20 mM	0.1339 mL	0.6694 mL	1.3387 mL	3.3468 mL
	25 mM	0.1071 mL	0.5355 mL	1.0710 mL	2.6774 mL
	30 mM	0.0892 mL	0.4462 mL	0.8925 mL	2.2312 mL
	40 mM	0.0669 mL	0.3347 mL	0.6694 mL	1.6734 mL
	50 mM	0.0535 mL	0.2677 mL	0.5355 mL	1.3387 mL
	60 mM	0.0446 mL	0.2231 mL	0.4462 mL	1.1156 mL
	80 mM	0.0335 mL	0.1673 mL	0.3347 mL	0.8367 mL
	100 mM	0.0268 mL	0.1339 mL	0.2677 mL	0.6694 mL

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ARN22089

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Ras アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

ARN22089

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Ras アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

ARN22089 関連分類

HY-149464 関連分類