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製品番号: HY-128128

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ASN04421891

Name: ASN04421891
Brand: MedChemExpress
SKU: HY-128128
Price: 300.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

ASN04421891 is a GPR17 agonist with nanomolar EC₅₀ and high specificity. ASN04421891 promotes oligodendrocyte precursor cell maturation to mature myelinating oligodendrocytes. ASN04421891 can be used for the research of cerebral ischaemia, cardiac ischaemia, renal ischaemia, cerebral trauma, multiple sclerosis, schizophrenia, depression, alzheimer's disease, alzheimer-like dementia, parkinson's disease, huntington's chorea, amyotrophic lateral sclerosis (ALS), neuroinflammatory disorders.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.00%
CAS 番号: 570365-12-7
分子式: C₃₀H₃₂N₆O₃
分子量:524.61

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

ASN04421891 構造式

CAS 番号: 570365-12-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

ASN04421891 exhibits an EC₅₀ of 3.67 nM as an agonist in GPR17-transfected human 1321N1 cells, with a potency reaching 142.8% of that of the reference agonist LTC₄^[1].
ASN04421891 (10 nM; 48 h) promotes the differentiation of primary rat oligodendrocyte precursor cells into mature, myelin basic protein-positive oligodendrocytes, with an activity of 140%-170% of that in the vehicle control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 570365-12-7
性状 Solid
分子量 524.61
分子式 C₃₀H₃₂N₆O₃
Color White to off-white
SMILES

O=C1NC2=C(C=C(OC)C=C2)C=C1C(C3=NN=NN3CCOC)N(CCC4=CC=CC=C4)CC5=CC=CC=C5
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Mariapia Abbracchio, et al. Gpr17-modulating compounds, diagnostic and therapeutic uses thereof. 2014-11-28. US20150094348A1.

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モル濃度計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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