Atacicept
Based on 1 publication(s) in Google Scholar
Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.84%
- CAS 番号: 845264-92-8
- 分子量:70.45 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Atacicept
More
生物活性
[TNFRSF13B]2-IGHG1 Fc
Human
Atacicept (TACI-Ig) inhibits the progression of disease and autoantibody titers in a mouse model of collagen-induced arthritis (CIA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male DBA/1 mice with CIA models[1]
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Dosage:100 μg
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Administration:intraperitoneal injection; three times of week for 21 days
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Result:Increased serum titers of anti-collagen Abs and few overt signs of disease.
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Animal Model:BALB/c mice[1]
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Dosage:100 μg
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Administration:intraperitoneal injection; three times of week for 14 days
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Result:Reduced mature B cell populations but had little effect on other cell lineages.
Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen.
Decerased the serum levels of IgM about 2.3-fold.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[TNFRSF13B (tumor necrosis factor receptor (TNFR)superfamily member 13B, TACI, transmembrane activator and CAML Interactor)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
化学情報
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CAS 番号 845264-92-8
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性状 Liquid
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分子量 70.45 kDa
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Color Colorless to light yellow
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SMILES
[Atacicept]
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別名
TACI-Ig; TACI-Fc 5
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
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データシート (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Gross JA, et, al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001 Aug;15(2):289-302. [Content Brief]
[2]. Gross JA, et, al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000 Apr 27;404(6781):995-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Atacicept 関連分類
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