BBIQ (GMP)
BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1229024-57-0
- 分子式: C21H22N4
- 分子量:330.43
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-111582
BBIQTLR7 Agonist -
HY-148068
STING agonist-20STING Agonist -
HY-123942
DiprovocimTLR1/TLR2 Agonist -
HY-P1180A
Pam3CSK4 TFATLR1/2 Agonist -
HY-W250113
Zymosan ATLR2 Agonist -
HY-146244
AgatolimodTLR9 Agonist -
HY-150724
ODN 1018TLR9 Agonist -
HY-150734
ODN 2007TLR Ligand -
HY-121496
3M-011TLR7/8 Agonist -
HY-150748
ODN D-SL01TLR9 Agonist -
HY-150742
ODN 2336TLR9 Agonists
生物活性
製品説明
IC50 & Target
|
human TLR7 59.1 nM (EC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.0591 μM
Compound: 31
|
Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay
Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay
|
[PMID: 20481492] |
化学情報
-
CAS 番号 1229024-57-0
-
分子量 330.43
-
分子式 C21H22N4
-
SMILES
NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=CC=C4
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Saroa R, et al. Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host. Bioorg Med Chem Lett. 2019 May 1;29(9):1099-1105. [Content Brief]
[2]. Kaushik D, et al. BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant. Hum Vaccin Immunother. 2020 Apr 16:1-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BBIQ (GMP) 関連分類
HY-111582G 関連分類
Powered by Bioz