β-Cryptoxanthin
β-Cryptoxanthin ((3R)-β-Cryptoxanthin) is an orally active carotenoid found in fruits and vegetables such as angerines, red peppers, and pumpkin. β-Cryptoxanthin inhibits prevents osteoclast formation and inhibits bone resorption. β-Cryptoxanthin maintains retinol status in vivo. β-cryptoxanthin shows anti-inflammation and anticancer activity. β-Cryptoxanthin can be used for the researches of osteoporosis and bladder carcer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.66%
- CAS 番号: 472-70-8
- 分子式: C40H56O
- 分子量:552.87
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Human Endogenous Metabolite |
β-Cryptoxanthin inhibits growth, upregulates RARβ mRNA, and transactivates RARE-mediated transcription in BEAS-2B lung epithelial cells in vitro[1].
β-Cryptoxanthin increase calcium content,
protein content, and alkaline phosphatase activity in bone[1].
β-Cryptoxanthin inhibits bone resorption in vitro by preventing osteoclast formation in mouse marrow cultures and inducing caspase-3-dependent apoptosis of mature osteoclastic cells, with synergistic effects alongside zinc[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
β-cryptoxanthin supplementation significantly decreases smoke-induced
squamous metaplasia and inflammation in the lung and lowers tumor necrosis factor a concentrations in lung tissue cells and macrophages in ferrets[1].
β-cryptoxanthin supplementation inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice, while restoring key regulatory gene expression and improving survival[1].
β-cryptoxanthin supplementation inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice[1].
β-Cryptoxanthin (50-500 µg/kg; p.o.; daily; 1 week) increases bone formation markers and prevents bone loss in multiple rat models of osteoporosis, with enhanced efficacy when combined with zinc[1].
β-Cryptoxanthin (0.05-1.75 mg/kg; p.o.; ad libitum in drinking water; 7 days) dose-dependently suppresses psychosocial stress-induced adrenal hypertrophy in male ddY mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rats with osteoporosis (young male, older female)[1]
-
Dosage:50, 100, 500 µg/kg
-
Administration:Oral; daily; 1 week
-
Result:Increased alkaline phosphatase activity and calcium concentrations in diaphyseal and metaphyseal tissues of young male and older female rats.
Prevented bone loss in streptozotocin-diabetic rats and ovariectomized rats.
Inhibited bone resorption.
Enhanced anabolic effects on bone components when combined with zinc sulfate.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 472-70-8
-
性状 Solid
-
分子量 552.87
-
分子式 C40H56O
-
Color Red to dark red
-
SMILES
CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](O)CC2(C)C)=C(C)CCC1
-
別名
(3R)-β-Cryptoxanthin
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (268 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
β-Cryptoxanthin 関連分類
HY-108059 関連分類
Powered by Bioz