BMP agonist 1
BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research.
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- 分子式: C21H16N2O6
- 分子量:392.36
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BMP agonist 1 (0.01-10 μM, 24 h) reduces the proliferation of C2C12 cells[1].
BMP agonist 1 (0.5-1 μM, 2 h) inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2 and Id3 expression in C2C12 cells[1].
BMP agonist 1 (0.01-10 μM) potently promotes the osteogenic differentiation (Alp activity) of the canonical BMP potentiator Chromenone 1 (HY-143891) in C2C12 cells when in combination with Chromenone 1 (0.5−1 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12 cells
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Concentration:0.01-10 μM
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Incubation Time:24, 72 h
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Result:Differentiaed in C2C12 osteoblast at the low-dose BMP-4 (7.5 ng/mL).
Reduced the cell numbers and stopped the proliferation at higher concentrations.
Highly induced Id1 and Id3, elevated Runx2 levels.
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Cell Line:C2C12 cells
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Concentration:0.01-10 μM (in combination with (0.05, 0.2, 0.5, or 1 μM Chromenone 1)
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Incubation Time:
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Result:Highly overadditive effects and increased potency with Chromenone 1.
Reached the highest synergy scores (i.e., delta scores) at a concentration of 0.3 μM with 0.5−1 μM Chromenone 1.
化学情報
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性状 Solid
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分子量 392.36
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分子式 C21H16N2O6
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Color Orange to red
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SMILES
OC1=CC2=C(C=C1)NC3=C2C(C(N4)=O)=C(C5=CC(OC)=C(C(OC)=C53)OC)C4=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (127.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5487 mL | 12.7434 mL | 25.4868 mL | 63.7170 mL |
| 5 mM | 0.5097 mL | 2.5487 mL | 5.0974 mL | 12.7434 mL | |
| 10 mM | 0.2549 mL | 1.2743 mL | 2.5487 mL | 6.3717 mL | |
| 15 mM | 0.1699 mL | 0.8496 mL | 1.6991 mL | 4.2478 mL | |
| 20 mM | 0.1274 mL | 0.6372 mL | 1.2743 mL | 3.1858 mL | |
| 25 mM | 0.1019 mL | 0.5097 mL | 1.0195 mL | 2.5487 mL | |
| 30 mM | 0.0850 mL | 0.4248 mL | 0.8496 mL | 2.1239 mL | |
| 40 mM | 0.0637 mL | 0.3186 mL | 0.6372 mL | 1.5929 mL | |
| 50 mM | 0.0510 mL | 0.2549 mL | 0.5097 mL | 1.2743 mL | |
| 60 mM | 0.0425 mL | 0.2124 mL | 0.4248 mL | 1.0619 mL | |
| 80 mM | 0.0319 mL | 0.1593 mL | 0.3186 mL | 0.7965 mL | |
| 100 mM | 0.0255 mL | 0.1274 mL | 0.2549 mL | 0.6372 mL |
BMP agonist 1 関連分類
HY-155705 関連分類
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