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United States

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製品番号: HY-107022

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BMS-341400

BMS-341400 is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC₅₀ value of 0.3 nM. BMS-341400 reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 can be used to study erectile dysfunction.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 296250-53-8
分子式: C₂₃H₂₂ClN₉O₂
分子量:491.93

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

BMS-341400 構造式

CAS 番号: 296250-53-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

PDE5

0.3 nM (IC₅₀)

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示 :

体外実験

BMS-341400 (Compound 6) effectively enhanced the relaxation of the smooth muscle in the isolated tissue of the rabbit penile corpus cavernosum, with its EC₅₀ value being 13 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	F	T_1/2
Dog	5.1 μmol/Kg	p.o.	42 %	2 h
Rat	2 μmol/Kg	p.o.	29 %	1.2 h

体内実験

BMS-341400 (Compound 6) (10-1000 nmol/kg, i.v., single dose) effectively promotes the erectile response in the male rabbit model with EC₅₀ value of 100 nmol/kg^[1].
BMS-341400 (10-250 mg/kg) demonstrates excellent safety in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Anesthesia-induced male rabbit model^[1]
Dosage:

10, 30, 100, 300, and 1000 nmol/kg
Administration:

Intravenous injection (i.v.), single dose
Result:

Had an equivalent efficacy in promoting erections in the body as Sildenafil (HY-15025).

化学情報

CAS 番号 296250-53-8
分子量 491.93
分子式 C₂₃H₂₂ClN₉O₂
SMILES

CCN1C2=C(C3=C(C(N4C=C(C(NC)=O)N=C4)=NN=C3NCC5=CC(Cl)=C(OC)C=C5)C=N2)C=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yu G, et al. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2003 Feb 13;46(4):457-60. [Content Brief]

[2]. Pryor JL, Redmon B. New therapies and delivery mechanisms for treatment of erectile dysfunction. International journal of impotence research. 2000 Oct;12(4):S158-62.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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