Braftide
Based on 1 Customer Validation
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.51%
- CAS 番号: 2411851-64-2
- 分子式: C57H94N16O13S
- 分子量:1243.52
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Immunology/Inflammation Compound Library
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生物活性
化学情報
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CAS 番号 2411851-64-2
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性状 Solid
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分子量 1243.52
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分子式 C57H94N16O13S
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Color White to off-white
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配列
Thr-Arg-His-Val-Asn-Ile-Leu-Leu-Phe-Met
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シーケンスの短縮
TRHVNILLFM
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (80.42 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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- English - EN (252 KB)
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- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8042 mL | 4.0208 mL | 8.0417 mL | 20.1042 mL |
| 5 mM | 0.1608 mL | 0.8042 mL | 1.6083 mL | 4.0208 mL | |
| 10 mM | 0.0804 mL | 0.4021 mL | 0.8042 mL | 2.0104 mL | |
| 15 mM | 0.0536 mL | 0.2681 mL | 0.5361 mL | 1.3403 mL | |
| 20 mM | 0.0402 mL | 0.2010 mL | 0.4021 mL | 1.0052 mL | |
| 25 mM | 0.0322 mL | 0.1608 mL | 0.3217 mL | 0.8042 mL | |
| 30 mM | 0.0268 mL | 0.1340 mL | 0.2681 mL | 0.6701 mL | |
| 40 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5026 mL | |
| 50 mM | 0.0161 mL | 0.0804 mL | 0.1608 mL | 0.4021 mL | |
| 60 mM | 0.0134 mL | 0.0670 mL | 0.1340 mL | 0.3351 mL | |
| 80 mM | 0.0101 mL | 0.0503 mL | 0.1005 mL | 0.2513 mL |
Braftide 関連分類
HY-P10436 関連分類
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