BW 755C
Based on 1 Customer Validation
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.0%
- CAS 番号: 66000-40-6
- 分子式: C10H10F3N3
- 分子量:229.20
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-14164
Zileuton5-Lipoxygenase Inhibitor -
HY-N2056
11-Keto-beta-boswellic acidAnti-inflammatory Agent -
HY-N2075
3-Acetyl-beta-boswellic acidNatural Product -
HY-125975
1-Naphthyl 3,5-dinitrobenzoate5-LOX Inhibitor -
HY-101051
2-TEDC5/12/15-Lipoxygenase Inhibitor -
HY-13750
EbselenVDCC Inhibitor -
HY-A0060
Malotilate5-LOX Inhibitor -
HY-118480
4-MMPB15-lipoxygenase Inhibitor -
HY-N0892
AKBANrf2 Activator -
HY-14164A
Zileuton sodium5-lipoxygenase Inhibitor -
HY-13419
U-73122Phospholipase C Inhibitor -
HY-14164R
Zileuton (Standard)5-Lipoxygenase Inhibitor
生物活性
製品説明
|
5-LO 5 μM (IC50) |
COX-1 0.65 μg/mL (IC50) |
COX-2 1.2 μg/mL (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RBL-1 | IC50 |
0.89 μM
Compound: BW-755C
|
In vitro inhibition of RBL-1 5-lipoxygenase; Value ranges from 0.72-1.07
In vitro inhibition of RBL-1 5-lipoxygenase; Value ranges from 0.72-1.07
|
[PMID: 3681891] |
| RBL-1 | IC50 |
1.3 μM
Compound: BW-755C
|
In vitro inhibitory activity against RBL-1 5-LO
In vitro inhibitory activity against RBL-1 5-LO
|
[PMID: 3820229] |
| RBL-1 | IC50 |
2 μM
Compound: BW-755C
|
Inhibition of 5-lipoxygenase in rat RBL-1 cells
Inhibition of 5-lipoxygenase in rat RBL-1 cells
|
[PMID: 2319562] |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Immature Wistar rats ~22 days of age[3]
-
Dosage:0.03, 0.1, 0.3, 1.0, 3.1 and 10 mg/rat
-
Administration:Subcutaneous injection, once
-
Result:Reduced 5-HETE (moderately) and 12-HETE (strongly).
化学情報
-
CAS 番号 66000-40-6
-
性状 Solid
-
分子量 229.20
-
分子式 C10H10F3N3
-
Color Brown to reddish brown
-
SMILES
NC1=NN(C2=CC=CC(C(F)(F)F)=C2)CC1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (436.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70. [Content Brief]
[2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [Content Brief]
[3]. Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260(2 Pt 1):E170-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3630 mL | 21.8150 mL | 43.6300 mL | 109.0750 mL |
| 5 mM | 0.8726 mL | 4.3630 mL | 8.7260 mL | 21.8150 mL | |
| 10 mM | 0.4363 mL | 2.1815 mL | 4.3630 mL | 10.9075 mL | |
| 15 mM | 0.2909 mL | 1.4543 mL | 2.9087 mL | 7.2717 mL | |
| 20 mM | 0.2182 mL | 1.0908 mL | 2.1815 mL | 5.4538 mL | |
| 25 mM | 0.1745 mL | 0.8726 mL | 1.7452 mL | 4.3630 mL | |
| 30 mM | 0.1454 mL | 0.7272 mL | 1.4543 mL | 3.6358 mL | |
| 40 mM | 0.1091 mL | 0.5454 mL | 1.0908 mL | 2.7269 mL | |
| 50 mM | 0.0873 mL | 0.4363 mL | 0.8726 mL | 2.1815 mL | |
| 60 mM | 0.0727 mL | 0.3636 mL | 0.7272 mL | 1.8179 mL | |
| 80 mM | 0.0545 mL | 0.2727 mL | 0.5454 mL | 1.3634 mL | |
| 100 mM | 0.0436 mL | 0.2182 mL | 0.4363 mL | 1.0908 mL |
BW 755C 関連分類
HY-119671 関連分類
Powered by Bioz