CA1001
CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
Human
CA1001 exhibits potent anti-tumor activity in melanoma cell lines[1].
CA1001 exerts a synergistic effect when combined with immune checkpoint inhibitors, significantly enhancing tumor regression in melanoma cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CA1001 (1-10 mg/kg, i.p., single administration) significantly reverses mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h[2].
CA1001 (1-10 mg/kg, i.p., single administration) significantly increases paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat[2]
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Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:i.p., once
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Result:Significantly reversed mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h.
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Animal Model:Rat[2]
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Dosage:1 mg/kg, 5 mg/kg, 10 mg/k
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Administration:i.p., once
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Result:Significantly increased paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia.
P07359
CD42b/GP1BA
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
化学情報
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SMILES
[CA1001]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CA1001 関連分類
HY-P992012 関連分類
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