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Cangrelor

(別名: AR-C69931MX)
4 Cited Publications
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Based on 4 publication(s) in Google Scholar

Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist.

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  • CAS 番号: 163706-06-7
  • 分子式: C17H25Cl2F3N5O12P3S2
  • 分子量:776.36
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Cangrelor Chemical Structure
    Cangrelor 構造式
  • Experimental Validation Results for Cangrelor
  • Experimental Validation Results for Cangrelor
  • Experimental Validation Results for Cangrelor
  • Experimental Validation Results for Cangrelor
CAS 番号: 163706-06-7
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  • Cangrelor Chemical Structure
    Cangrelor Chemical Structure
    1/16
  • 1/16

    Cangrelor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct 23:117451. [Abstract]

    Customer Validation
     Determination of Avibactam, Lopromide, Cangrelor tetrasodium, Protirelin, and Ioxilan IC50 values in Huh7 and Hep3B cells.

  • 1/16

    Cangrelor purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]

    Customer Validation
     Weight changes in mice infected with and treated with H1N1-UI182. The combined results of the two studies showed that treatment with glecaprevir, Cangrelor tetrasodium (Cangrelor), acarbose, and everolimus significantly slowed the rate of weight loss in virus-infected mice.

  • 1/16

    Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

    Customer Validation
     The EA. hy926 cells were pretreated with vehicle (M), OG-5 for 2 hours followed by stimulated with ADP for 4 hours, then the treated cells and supernatants were collected. The release of MCP-1 and VCAM-1 in supernatant were determined by ELISA kit and adhesion molecule ICAM-1 was determined in cell lysates. The results showed that treatment with OG-5 significantly inhibited the increase in ADP-induced MCP-1 and VCAM-1 production, showing a comparable effect with Cangrelor tetrasodium (0.5 µM) at the concentration of 0.5 mM.

  • 1/16

    Cangrelor purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]

    Customer Validation
     Immunoblotting and densitometric analyses of p-VASP (Ser157). Platelets were preincubated with vehicle and different concentrations of OG-5 for 5 min at 37 ℃, in the presence or absence of the specific inhibitors and then stimulated with agonist. The reaction was stopped by addition of RIPA buffer immediately and the cell lysates were applied to immunoblot analysis with phospho-specific antibody. The results showed that Cangrelor tet (0.5 μM) attenuated the 2MeS-ADP-induced reduction in p-VASP(S157) levels.

  • Cangrelor