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United States

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製品番号: HY-P12357

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CD27 peptide

CD27 peptide is a 13-amino acid peptide derived from CD27. CD27 peptide is a targeting ligand for CD70 and can be used to construct CD70-targeted peptide amphiphile micelles. CD27 peptide can be used for research on melanoma and clear cell renal cell carcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3037125-72-4
分子式: C₅₄H₉₂N₁₈O₁₇S₃
分子量:1361.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

CD27 peptide 構造式

CAS 番号: 3037125-72-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CD27 peptide (99:1 peptide:siRNA ratio; 1 h) incorporation into HIF2α-CD27 PAMs successfully retains HIF2α siRNA and protects it from RNase degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

Animal Model:

C57BL/6 (Female human CD27 transgenic (hCD27), aged 6-12 weeks)^[2]
Dosage:

100 µg
Administration:

i.p.; on days 3 and 6 after tumor implantation
Result:

Increased Ova(I)-specific CD8+ T cells from ~20% to ~50% of the CD8+ TIL population.
Extended median survival by 18 days compared to control animals.\nProlonged survival in the setting of vaccines comprised of linked class I and II epitopes (Ova(I-IIA)).
Had no effect on survival with Ova(I) or Ova(I) + Ova(IIA) vaccines.\nProlonged survival in hCD27 mice bearing intracranial B16.OVA tumors.

Animal Model:

C57BL/6 (Female human CD27 transgenic (hCD27), aged 6-12 weeks)^[2]
Dosage:

100 µg
Administration:

i.p.; on days 3 and 6 after tumor implantation
Result:

Prolonged survival in mice bearing 3-day established intracranial B16.F10 tumors when combined with Trp2(I)-P30.
Had no effect on survival relative to control groups when combined with Trp2(I).

化学情報

CAS 番号 3037125-72-4
分子量 1361.61
分子式 C₅₄H₉₂N₁₈O₁₇S₃
配列

Cys-Arg-Lys-Ala-Ala-Gln-Cys-Asp-Pro-Cys-Ile-Pro-Gly
シーケンスの短縮

CRKAAQCDPCIPG
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Trac N, et al. CD70-Targeted Micelles Enhance HIF2α siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells. Molecules (Basel, Switzerland). 2022 Dec 02;27(23):8457.

[2]. Riccione KA, et al. CD27 stimulation unveils the efficacy of linked class I/II peptide vaccines in poorly immunogenic tumors by orchestrating a coordinated CD4/CD8 T cell response. Oncoimmunology. 2018 Sep 5;7(12):e1502904.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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