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製品番号: HY-128061

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CDIBA

CDIBA is a cytosolic phospholipase A2 (cPLA2) inhibitor. CDIBA inhibits the activation of cPLA2 in rat diaphragm tissue. CDIBA reduces the level of mitochondrial reactive oxygen species in rat diaphragm tissue after prolonged mechanical ventilation. CDIBA attenuates protein degradation, muscle atrophy and decreased muscle strength in the diaphragm of rats after prolonged mechanical ventilation. CDIBA can be used in studies related to ventilator-induced diaphragmatic dysfunction.

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CAS 番号: 479422-22-5
分子式: C₃₁H₂₆ClNO₃
分子量:496.00

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDIBA 構造式

CAS 番号: 479422-22-5

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Phospholipase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MC9	Inhibition	-8 % Compound: 25	Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM Inhibition of PGF2-alpha production in the presence of exogenous arachidonic acid in MC9 cell at 1.5 uM	[PMID: 16392799]
MC9	Inhibition	81 % Compound: 25	Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM Inhibition of PGF2-alpha production in MC9 cells at 1.5 uM	[PMID: 16392799]
MC9	Inhibition	96 % Compound: 25	Inhibition of LTB4 production in MC9 cells at 1.5 uM Inhibition of LTB4 production in MC9 cells at 1.5 uM	[PMID: 16392799]

体内実験

CDIBA (30 mg/kg; i.p.; single injection at ventilation onset; 5 mg/kg/h; i.v.; continuous infusion; 12 hours) attenuates ventilator-induced diaphragm dysfunction in rats by reducing cPLA2 activation, mitochondrial ROS production, calpain activity, muscle atrophy, and improving diaphragm contractile force^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (adult male, SPF level, 450-550 g, ventilator-induced diaphragm dysfunction model)^[1]
Dosage:

30 mg/kg (i.p. injection); 5 mg/kg/h (continuous i.v. infusion)
Administration:

i.p. (single injection at ventilation onset); i.v. (continuous infusion; 12 hours)
Result:

Significantly reduced cPLA2 activation in the diaphragm.
Decreased mitochondrial H₂O₂ production in the diaphragm.
Downregulated diaphragm calpain activity.
Reduced the expression of atrophy-related genes Atrogin-1 and MuRF-1 in the diaphragm.
Increased the cross-sectional area of slow-twitch and fast-twitch diaphragm muscle fibers.
Improved diaphragm contractile function, including increased maximal tetanic forces, elevated force-frequency curve responses, and enhanced fatigue tolerance, compared to untreated ventilated rats.

化学情報

CAS 番号 479422-22-5
分子量 496.00
分子式 C₃₁H₂₆ClNO₃
SMILES

O=C(O)C1=CC=C(OCCC=2C=3C=C(Cl)C=CC3N(C2C)C(C=4C=CC=CC4)C=5C=CC=CC5)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhou XL, et al. Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction. Oxid Med Cell Longev. 2019;2019:2561929. Published 2019 Apr 18. [Content Brief]

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