CEE321
Based on 1 Customer Validation
CEE321 is a potent pan-JAK inhibitor with an IC50 value of 54 nM. CEE321 potently inhibits biomarkers associated with atopic dermatitis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.74%
- CAS 番号: 2098545-89-0
- 分子式: C18H16ClN5O
- 分子量:353.81
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
生物活性
製品説明
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2098545-89-0
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性状 Solid
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分子量 353.81
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分子式 C18H16ClN5O
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Color Off-white to light yellow
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SMILES
O=C(C1=CN=C(NC2=CC=CC(C)=N2)C=C1NC3=C(Cl)C=CC=C3)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (282.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8264 mL | 14.1319 mL | 28.2638 mL | 70.6594 mL |
| 5 mM | 0.5653 mL | 2.8264 mL | 5.6528 mL | 14.1319 mL | |
| 10 mM | 0.2826 mL | 1.4132 mL | 2.8264 mL | 7.0659 mL | |
| 15 mM | 0.1884 mL | 0.9421 mL | 1.8843 mL | 4.7106 mL | |
| 20 mM | 0.1413 mL | 0.7066 mL | 1.4132 mL | 3.5330 mL | |
| 25 mM | 0.1131 mL | 0.5653 mL | 1.1306 mL | 2.8264 mL | |
| 30 mM | 0.0942 mL | 0.4711 mL | 0.9421 mL | 2.3553 mL | |
| 40 mM | 0.0707 mL | 0.3533 mL | 0.7066 mL | 1.7665 mL | |
| 50 mM | 0.0565 mL | 0.2826 mL | 0.5653 mL | 1.4132 mL | |
| 60 mM | 0.0471 mL | 0.2355 mL | 0.4711 mL | 1.1777 mL | |
| 80 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8832 mL | |
| 100 mM | 0.0283 mL | 0.1413 mL | 0.2826 mL | 0.7066 mL |