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製品番号: HY-117559

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CGP-75355

CGP-75355 is an inhibitor of HIV-1 protease with IC₅₀ of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 191594-64-6
分子式: C₃₉H₅₃N₅O₇
分子量:703.87

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CGP-75355 構造式

CAS 番号: 191594-64-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CGP-75355 is an inhibitor of HIV-1 protease with IC₅₀ of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative^[1]^[2].

HIV アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	ED₅₀	0.7 nM Compound: 25a	Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells. Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells.	[PMID: 9719591]
MT2	IC₅₀	58 nM Compound: 25a	The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells. The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.	[PMID: 9719591]

化学情報

CAS 番号 191594-64-6
分子量 703.87
分子式 C₃₉H₅₃N₅O₇
SMILES

CC(C)(C)[C@@H](C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC2=CC=C(C3=CC=CC=C3)C=C2)=O)NC(OC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bold, G., et al., (1998). New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development. Journal of medicinal chemistry, 41(18), 3387-3401. [Content Brief]

[2]. Wieslaw M. Kazmierski, (2011). Antiviral Drugs: From Basic Discovery Through Clinical Trials.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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