CGP78850
Based on 2 publication(s) in Google Scholar
CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.47%
- CAS 番号: 258326-83-9
- 分子式: C36H46N5O9P
- 分子量:723.75
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 CGP78850
More
生物活性
Grb2 SH2-phosphopeptide[1]
CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1].
CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-468 cells
-
Concentration:0~100 μM
-
Incubation Time:90 minutes
-
Result:Reduced the amount of associated Grb2 protein in a dose-dependent manner.
化学情報
-
CAS 番号 258326-83-9
-
性状 Solid
-
分子量 723.75
-
分子式 C36H46N5O9P
-
Color White to off-white
-
SMILES
O=P(O)(O)CC(C=C1)=CC=C1C[C@H](NC(C)=O)C(NC2(CCCCC2)C(N[C@@H](CC(N)=O)C(NCCCC3=C(O)C=CC4=C3C=CC=C4)=O)=O)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
-
Arch Dermatol Res
IL-22-mediated microRNA-124-3p/GRB2 axis regulates hyperproliferation and inflammatory response of keratinocytes in psoriasis. [Abstract]2025 Jan 10;317(1):227. PMID: 39792268
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (138.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3817 mL | 6.9085 mL | 13.8169 mL | 34.5423 mL |
| 5 mM | 0.2763 mL | 1.3817 mL | 2.7634 mL | 6.9085 mL | |
| 10 mM | 0.1382 mL | 0.6908 mL | 1.3817 mL | 3.4542 mL | |
| 15 mM | 0.0921 mL | 0.4606 mL | 0.9211 mL | 2.3028 mL | |
| 20 mM | 0.0691 mL | 0.3454 mL | 0.6908 mL | 1.7271 mL | |
| 25 mM | 0.0553 mL | 0.2763 mL | 0.5527 mL | 1.3817 mL | |
| 30 mM | 0.0461 mL | 0.2303 mL | 0.4606 mL | 1.1514 mL | |
| 40 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL | 0.8636 mL | |
| 50 mM | 0.0276 mL | 0.1382 mL | 0.2763 mL | 0.6908 mL | |
| 60 mM | 0.0230 mL | 0.1151 mL | 0.2303 mL | 0.5757 mL | |
| 80 mM | 0.0173 mL | 0.0864 mL | 0.1727 mL | 0.4318 mL | |
| 100 mM | 0.0138 mL | 0.0691 mL | 0.1382 mL | 0.3454 mL |
CGP78850 関連分類
HY-129800 関連分類
Powered by Bioz