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製品番号: HY-117435

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CIDD 0067106

CIDD-0067106 is a selective mTORC1 pathway inhibitor targeting androgen receptor-positive (AR+) triple-negative breast cancer (TNBC). CIDD-0067106 demonstrates potent inhibition of AR+ TNBC cell lines with an GI₅₀ value of 0.8 μM. CIDD-0067106 is promising for research of AR+ TNBC.

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CAS 番号: 2151865-39-1
分子式: C₂₆H₂₉N₃O₄
分子量:447.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CIDD 0067106 構造式

CAS 番号: 2151865-39-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

mTORC1

mTOR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A10	GI₅₀	35 μM Compound: 30	Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
BT-549	GI₅₀	40 μM Compound: 30	Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1806	GI₅₀	30 μM Compound: 30	Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1937	GI₅₀	35 μM Compound: 30	Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-231	GI₅₀	50 μM Compound: 30	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-453	GI₅₀	0.8 μM Compound: 30	Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
SUM185PE	GI₅₀	1.6 μM Compound: 30	Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]

化学情報

CAS 番号 2151865-39-1
分子量 447.54
分子式 C₂₆H₂₉N₃O₄
SMILES

C(C1=CC=C(C=2OC(=CN2)C3=CC=C(OCC=C(C)C)C=C3)N=C1)N4[C@H](C(OC)=O)CCC4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Robles AJ, et al. Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells. J Med Chem. 2017 Nov 22;60(22):9275-9289. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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CIDD 0067106

mTOR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CIDD 0067106 関連分類

HY-117435 関連分類