Ciduvectamig
Based on 1 Customer Validation
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.879%
- CAS 番号: 2412587-62-1
- 分子量:143.771 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
IgG4-kappa-lambda
Human
CD3E & TMEFF2
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG4-kappa-lambda
ELISA, FACS, Functional assay
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Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, His) (HY-P72726) can bind Ciduvectamig. The EC50 for this effect is 40.92 ng/mL. -
Immobilized TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) (HY-P700470) can bind Ciduvectamig. The EC50 for this effect is 297.4 ng/mL. -
Flow cytometric analysis of 1X106 FaDu cells with Ciduvectamig (HY-P990692, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black). -
Flow cytometric analysis of 1X106 Jurkat cells with Ciduvectamig (HY-P990692, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
化学情報
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CAS 番号 2412587-62-1
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性状 Liquid
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分子量 143.771 kDa
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Color Colorless to light yellow
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SMILES
[Ciduvectamig]
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別名
JNJ-70218902; JNJ-902
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (253 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Ciduvectamig
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)