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United States

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製品番号: HY-P11422

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CKS9

CKS9 is an M cell-targeting polypeptide with the amino acid sequence CKSTHPLSC, forming a 9-mer peptide via cyclization through a disulfide bond between the two cysteine residues. CKS9 is obtained through phage display technology screening and has high affinity for M cells. CKS9 can promote chitosan nanoparticles to cross M cells and enter the follicle-associated epithelium (FAE) of intestinal Peyer's patches (PP). CKS9 can be used in studies related to swine dysentery and oral delivery.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₉H₆₄N₁₂O₁₃S₂
分子量:973.13

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CKS9 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CKS9 can be successfully grafted onto stearic acid esterified starch to form SES@CKS9-1 and SES@CKS9-2^[1].
CKS9-modified SES exhibits stronger binding affinity to integrin α5β1 than unmodified SES. CKS9 mediates key hydrogen-bond interactions at the interface of the βI/β-propeller domain of integrin, suggesting that integrin α5β1 is a potential M cell receptor for CKS9^[1].
CKS9 is conjugated with WSC via EDC/NHS, with a molar ratio of 6.37 mol%^[2].
As the C-terminal component of a computationally designed multi-epitope oral vaccine against *Helicobacter pylori*, CKS9 targets intestinal epithelial microfold cells to enhance the intestinal barrier uptake of the vaccine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 973.13
分子式 C₃₉H₆₄N₁₂O₁₃S₂
配列

Cys-Lys-Ser-Thr-His-Pro-Leu-Ser-Cys (Disulfide bridge:Cys1-Cys9)
シーケンスの短縮

CKSTHPLSC (Disulfide bridge:Cys1-Cys9)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (260 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang T, et al. Development of M cell-targeting starch-based nanomicelles for oral delivery of immunoactive peptides[J]. Industrial Crops and Products, 2022, 184: 115074.

[2]. Jiang T, et al. Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan. Biomaterials. 2014 Feb;35(7):2365-73. [Content Brief]

[3]. Urrutia-Baca VH, et al. Immunoinformatics Approach to Design a Novel Epitope-Based Oral Vaccine Against Helicobacter pylori. J Comput Biol. 2019 Oct;26(10):1177-1190.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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