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製品番号: HY-187683

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CN045

CN045 is a blood-brain barrier-permeable, selective M1 muscarinic receptor ligand with an IC₅₀ value of 1 μM. CN045 enhances remyelination in mouse brain regions. CN045 can be used in studies related to multiple sclerosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 401809-27-6
分子式: C₁₆H₂₂Cl₃NO₂
分子量:366.71

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CN045 構造式

CAS 番号: 401809-27-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

mAChR1

1 μM (IC₅₀)

mAChR アイソフォーム固有の製品をすべて表示 :

体外実験

CN045 (5 days) potently promotes differentiation of primary mouse PLP-EGFP transgenic oligodendrocyte progenitor cells in vitro with an EC₅₀ of 40 nM, yielding a higher percentage of mature oligodendrocytes than Clemastine (HY-B0298)^[1].
CN045 (5 days) potently stimulates differentiation of primary mouse OPCs into mature, myelin protein-expressing oligodendrocytes with an EC₅₀ of 0.04 μM^[2].
CN045 (1 μM; 14 days) promotes myelin-like ensheathment of engineered nanofibers by primary mouse OPCs, increasing both oligodendrocyte numbers and ensheathment length^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

CN045 (10 mg/kg; i.p.; daily; 6 weeks) significantly enhances remyelination in both white and gray matter regions of Cuprizone (HY-W115718)/Sirolimus (HY-10219)-demyelinated C57/BL/6J mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57/BL/6J (8-week-old male; multiple sclerosis model via 12 weeks of 0.3% cuprizone chow plus daily i.p. sirolimus 10 mg/kg-induced demyelination)^[2]
Dosage:

10 mg/kg
Administration:

i.p.; daily; 6 weeks
Result:

Increased remyelination in the corpus callosum, hippocampus, and cerebral cortex compared to vehicle treatment.
Increased the number of PPD+ myelinated axons per unit area in the corpus callosum.
Increased the percentage area of PLP staining in the hippocampus.
Increased the percentage area of PLP staining in the cerebral cortex.

化学情報

CAS 番号 401809-27-6
分子量 366.71
分子式 C₁₆H₂₂Cl₃NO₂
SMILES

ClC1=C(OCCOCCN2CCC(C)CC2)C(Cl)=CC(Cl)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Raubenolt B, et al. Structural Basis of M1 Muscarinic and H3 Histamine Receptor Inhibition in OPC Differentiation[J]. bioRxiv, 2026: 2026.04. 01.715893.

[2]. Yang Y, et al. A novel small molecule remyelination therapy for multiple sclerosis. npj drug discovery. 2026 Jul 23;3(1):24.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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