CP2-CPP
CP2-CPP is a conjugate of p27 Analogue CP2 (HY-P11020) and Antennapedia Peptide (HY-P0307). CP2-CPP crosses cell membranes and localizes to live cell cytosol. CP2-CPP blocks SCFSkp2/Cks1-p27 interaction to inhibit p27 ubiquitination and degradation, restoring p27 levels and inhibiting cell proliferation. CP2-CPP can be used for the research of cancer, such as breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C155H249N54O39PS
- 分子量:3556.01
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Skp2 |
CP2-CPP (24 h) exhibits high resistance to GluC protease digestion, with almost 90% of the peptide remaining intact after 24 hours of treatment at 37 °C[1].
CP2-CPP (16 h) restores p27 protein levels to control levels in Skp2/Cks1-transfected MCF-7 human breast cancer cells[1].
CP2-CPP (20 μM; 16 h) inhibits DNA replication by 35% in MCF-7 human breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 human breast cancer cells
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Concentration:20 μM
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Incubation Time:16 h
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Result:Inhibited DNA replication by 35%, which is 2.5 times greater than the small 10% inhibitory effects observed with control peptides (CPP only, linear-CPP, Control-CPP).
化学情報
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分子量 3556.01
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分子式 C155H249N54O39PS
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SMILES
NCCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCN3C=C(CCNC(NCCC4=CN(CC[C@@H](C(N[C@@H](CCC(O)=O)C(N5)=O)=O)NC([C@H](CO)NC(CNC([C@@H](N)C)=O)=O)=O)N=N4)=O)N=N3)NC([C@H]6N(C([C@H]([C@H](OP(O)(O)=O)C)NC([C@@H]5CCC(N)=O)=O)=O)CCC6)=O)=O)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCCCN)=O)[C@H](CC)C)=O)=O)CC7=CC=CC=C7)=O)CCC(N)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCSC)=O)CCCCN)=O)CC8=CNC9=CC=CC=C89)=O)CCCCN)=O)C(O)=O
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配列
Ala-Gly-Ser-{X2}-Glu-Gln-Thr{phos}-Pro-{X3}-Lys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys
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シーケンスの短縮
AGS-{X2}-EQ-Thr{phos}-P-{X3}-KRQIKIWFQNRRMKWKK
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CP2-CPP 関連分類
HY-P11792 関連分類
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