cTMTP1
cTMTP1 (Cyclic TMTP1) is the cyclic form of TMTP1 (HY-P11815). TMTP1 is a tumor-targeting peptide that selectively targets highly metastatic tumor cells. The cTMTP1-based [68Ga]Ga-DOTA-cTMTP1 probe is used for visualization of hepatocellular carcinoma. cTMTP1 can form a 68Ga-DOTA radiotracer that accumulates in highly metastatic cervical cancer cells and is used for microPET tumor visualization. cTMTP1 is applicable to research related to hepatocellular carcinoma and cervical cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C35H60N14O12S2
- 分子量:933.07
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Radionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示
More
生物活性
|
RDC Peptide |
cTMTP1-based radiotracer 68Ga-DOTA-TMTP1 (~18.5 KBq/well; 15-120 min; 10 μg cold cyclic TMTP1 pre-incubated for 15 min followed by 60-120 min incubation) exhibits specific, high uptake and retention in highly metastatic HeLa cervical cancer cells compared to low metastatic C-33A cells and normal End1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[68Ga]Ga-DOTA-cTMTP1 (i.v.; single dose) maintains high tumor-to-liver ratios (ranging from 2.20 to 2.55) and enables sensitive detection of small HCC lesions in transgenic c-Myc liver tumor mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude (male, 5−6 weeks old, ~20 g, subcutaneous xenograft via right forelimb axillary injection of 2×106 SMMC-7721 cells)[1]
-
Dosage:5.2 MBq
-
Administration:i.v.; single dose
-
Result:Reached tumor uptake of 1.3 %ID/g at 15 min, 1.09 %ID/g at 30 min, and 0.74 %ID/g at 150 min postinjection.
Achieved tumor-to-liver ratios of 2.65 at 30 min, 2.37 at 60 min, 2.14 at 120 min, and 2.69 at 150 min postinjection.
Reached tumor-to-muscle ratio of 11.17 at 150 min postinjection.
Exhibited blood clearance of 1.11 %ID/g at 30 min, 0.48 %ID/g at 60 min, and 0.22 %ID/g at 120 min postinjection.
Reduced tumor uptake to 0.36 %ID/g at 30 min and 0.32 %ID/g at 60 min postinjection upon coinjection of excess linear TMTP1 (p < 0.01).
化学情報
-
分子量 933.07
-
分子式 C35H60N14O12S2
-
別名
Cyclic TMTP1
-
配列
cyclo(Cys-Gly-Asn-Val-Val-Arg-Gln-Gly-Cys) (Disulfide bridge: Cys1-Cys9)
-
シーケンスの短縮
cyclo(CGNVVRQGC) (Disulfide bridge: Cys1-Cys9)
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Meng Z, et al. Development of a Cyclic TMTP1-Based PET Probe for Visualization of Hepatocellular Carcinoma. ACS medicinal chemistry letters. 2025 Apr 10;16(4):617-624. [Content Brief]
[2]. Chen X, et al. Ga-labeled TMTP1 radiotracer for PET imaging of cervical cancer. American journal of nuclear medicine and molecular imaging. 2024;14(2):110-121. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
cTMTP1 関連分類
HY-P11814 関連分類
Powered by Bioz
- cTMTP1
- Cyclic TMTP1
- cTMTP 1
- cTMTP-1
- Cyclic TMTP 1
- Cyclic TMTP-1
- Radionuclide-Drug Conjugates (RDCs)
- Drug Derivative
- cervical cancer
- HCC mouse models
- HeLa cervical cancer cells
- C-33A cells
- hepatocellular carcinoma
- End1 cells
- transgenic c-Myc liver tumor mice
- highly metastatic tumor cells
- XPNPEP2
- subcutaneous HCC xenograft mice
- Inhibitor
- inhibitor
- inhibit