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製品番号: HY-161326

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CXF-007

CXF-007 is a potent and specific FGFR4 inhibitor with a IC₅₀ value of 7 nM. CXF-007 has antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2727083-99-8
分子式: C₃₄H₃₃N₇O₅
分子量:619.67

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CXF-007 構造式

CAS 番号: 2727083-99-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

CXF-007 is a potent and specific FGFR4 inhibitor with a IC₅₀ value of 7 nM. CXF-007 has antitumor activity^[1].

IC₅₀ & Target

FGFR4

7 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>5000 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	1 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR4 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	170 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR3 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	445 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
BaF3	IC₅₀	530 nM Compound: CXF-007	Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK-8 assay	[PMID: 38432058]
HCC1937	IC₅₀	3.36 μM Compound: CXF-007	Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCC1937 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Hep 3B2	IC₅₀	0.77 μM Compound: CXF-007	Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay Antiproliferative activity against human Hep3B cells after 72 hrs by CCK8 assay	[PMID: 38432058]
Huh-7	IC₅₀	1.16 μM Compound: CXF-007	Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay Antiproliferative activity against human Huh-7 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
MDA-MB-453	IC₅₀	0.37 μM Compound: CXF-007	Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay	[PMID: 38432058]
NCI-H1299	IC₅₀	>10 μM Compound: CXF-007	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK8 assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK8 assay	[PMID: 38432058]

化学情報

CAS 番号 2727083-99-8
分子量 619.67
分子式 C₃₄H₃₃N₇O₅
SMILES

COC1=CC(OC)=CC(N(C2)C(N(CCC3=CC=C(NC(C=C)=O)C=C3)C4=C2C=NC(NC5=C(NC(C=C)=O)C=CC=C5)=N4)=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chen X, et al. Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4. Eur J Med Chem. 2024 Feb 28;268:116281. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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