D-Alanine-d4
Based on 1 Customer Validation
D-Alanine-d4 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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- 純度: 99.97%
- CAS 番号: 1202063-27-1
- 分子式: C3H3D4NO2
- 分子量:93.12
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 1202063-27-1
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非標識Cas 338-69-2
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性状 Solid
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分子量 93.12
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分子式 C3H3D4NO2
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Color White to off-white
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SMILES
N[C@@](C([2H])([2H])[2H])([2H])C(O)=O
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別名
(R)-Alanine-d4; Ba 2776-d4; D-α-Alanine-d4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : ≥ 125 mg/mL (1342.35 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27. [Content Brief]
[3]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 10.7388 mL | 53.6942 mL | 107.3883 mL | 268.4708 mL |
| 5 mM | 2.1478 mL | 10.7388 mL | 21.4777 mL | 53.6942 mL | |
| 10 mM | 1.0739 mL | 5.3694 mL | 10.7388 mL | 26.8471 mL | |
| 15 mM | 0.7159 mL | 3.5796 mL | 7.1592 mL | 17.8981 mL | |
| 20 mM | 0.5369 mL | 2.6847 mL | 5.3694 mL | 13.4235 mL | |
| 25 mM | 0.4296 mL | 2.1478 mL | 4.2955 mL | 10.7388 mL | |
| 30 mM | 0.3580 mL | 1.7898 mL | 3.5796 mL | 8.9490 mL | |
| 40 mM | 0.2685 mL | 1.3424 mL | 2.6847 mL | 6.7118 mL | |
| 50 mM | 0.2148 mL | 1.0739 mL | 2.1478 mL | 5.3694 mL | |
| 60 mM | 0.1790 mL | 0.8949 mL | 1.7898 mL | 4.4745 mL | |
| 80 mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 3.3559 mL | |
| 100 mM | 0.1074 mL | 0.5369 mL | 1.0739 mL | 2.6847 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Alanine-d4 関連分類
HY-41700S1 関連分類
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