DBI-2
DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells.
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- CAS 番号: 2939087-00-8
- 分子式: C24H29BrN2O3
- 分子量:473.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
The IC50 of DBI-2 to inhibit the proliferation of LS174T cells and HCT116 cells was 1.14 μM and 0.53 μM, respectively[1].
DBI-2 (3 μM; 24 h) induces growth suppression by activating AMPK and inhibiting the mTOR and Wnt pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LS174T CRC cells
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Concentration:3 μM
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Incubation Time:24 h
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Result:Increased p-AMPK and p-ACC, and decreased p-P70S6K and p-S6, and reduced the expression of Axin2 and c-Myc.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RAG1−/− γc− mice injected with S174T cells[1]
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Dosage:40 mg/kg
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Administration:Intraperitoneal administration; for 12 days
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Result:Suppressed of tumor growth.
化学情報
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CAS 番号 2939087-00-8
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分子量 473.40
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分子式 C24H29BrN2O3
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SMILES
CN(CCN(C)CCCCOC1=CC=C2C(OC=C(C3=CC=C(Br)C=C3)C2=O)=C1)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DBI-2 関連分類
HY-162516 関連分類
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