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製品番号: HY-137996

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Dehydrovomifoliol

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Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .

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純度: 98.88%
CAS 番号: 39763-33-2
分子式: C₁₃H₁₈O₃
分子量:222.28

保管条件:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Dehydrovomifoliol 構造式

CAS 番号: 39763-33-2

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Akt アイソフォーム固有の製品をすべて表示 :

mTOR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>64.4 μM Compound: 12	Cytostatic activity against human A549 cells after 48 cells by MTT assay Cytostatic activity against human A549 cells after 48 cells by MTT assay	[PMID: 21561060]
C8166	CC₅₀	>450.5 μM Compound: 12	Cytotoxicity against human C8166 cells after 3 days by MTT assay Cytotoxicity against human C8166 cells after 3 days by MTT assay	[PMID: 21561060]
C8166	EC₅₀	>450.5 μM Compound: 12	Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay	[PMID: 21561060]
HL-60	IC₅₀	>64.4 μM Compound: 12	Cytostatic activity against human HL60 cells after 48 cells by MTT assay Cytostatic activity against human HL60 cells after 48 cells by MTT assay	[PMID: 21561060]
HT-29	IC₅₀	>10 μM Compound: S7	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
HT-29	IC₅₀	>10 μM Compound: S7	Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay	[PMID: 30057155]
MCF7	IC₅₀	>64.4 μM Compound: 12	Cytostatic activity against human MCF7 cells after 48 cells by MTT assay Cytostatic activity against human MCF7 cells after 48 cells by MTT assay	[PMID: 21561060]
MDA-MB-435	IC₅₀	>10 μM Compound: S7	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
OVCAR-3	IC₅₀	>10 μM Compound: S7	Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
RAW264.7	IC₅₀	>50 μM Compound: 10	Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA	[PMID: 24963714]
RAW264.7	IC₅₀	>64.4 μM Compound: 12	Antiinflammatory against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production Antiinflammatory against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production	[PMID: 21561060]
RAW264.7	IC₅₀	38.5 μM Compound: 10	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay	[PMID: 24963714]
SMMC-7721	IC₅₀	>64.4 μM Compound: 12	Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay	[PMID: 21561060]
SW480	IC₅₀	>64.4 μM Compound: 12	Cytostatic activity against human SW480 cells after 48 cells by MTT assay Cytostatic activity against human SW480 cells after 48 cells by MTT assay	[PMID: 21561060]

化学情報

CAS 番号 39763-33-2
性状 Oil
分子量 222.28
分子式 C₁₃H₁₈O₃
Color Colorless to light yellow
SMILES

CC(/C=C/[C@](C(C)(C1)C)(C(C)=CC1=O)O)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ma J, et al. Dehydrovomifoliol Alleviates Nonalcoholic Fatty Liver Disease via the E2F1/AKT/mTOR Axis: Pharmacophore Modeling and Molecular Docking Study. Evid Based Complement Alternat Med. 2023 Feb 1;2023:9107598. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
化学情報
純度とドキュメンテーション
参考文献

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Dehydrovomifoliol

Akt アイソフォーム固有の製品をすべて表示

mTOR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Dehydrovomifoliol 関連分類

HY-137996 関連分類