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United States

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製品番号: HY-N19628

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Dianellin

Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 58829-72-4
分子式: C₂₅H₃₂O₁₂
分子量:524.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Dianellin 構造式

CAS 番号: 58829-72-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

Dianellin weakly binds to Plasmodium falciparum plasmepsin II and does not bind to Plasmodium falciparum pfLDH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Dianellin (25-100 mg/kg; i.g.; daily; 4 days) exhibits dose-dependent in vivo anti-malarial activity against Plasmodium berghei in Swiss albino mice, with an ED₅₀ of 92.31 mg/kg and up to 53.77% parasitaemia suppression at the highest tested dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino (5-6 weeks old, 20-25 g, male or female, intraperitoneally inoculated with Plasmodium berghei ANKA strain-infected erythrocytes)^[1]
Dosage:

25, 50, 100 mg/kg
Administration:

p.o.; daily; 4 days
Result:

Achieved 29.83% parasitaemia suppression and a mean survival time of 7.6 days at 25 mg/kg/day.
Achieved 44.04% parasitaemia suppression and a mean survival time of 8.2 days at 50 mg/kg/day.
Achieved 53.77% parasitaemia suppression and a mean survival time of 8.2 days at 100 mg/kg/day.
Demonstrated statistically significant suppression compared to negative control (p < 0.001).
Had a median effective dose (ED₅₀) of 92.31 mg/kg.

化学情報

CAS 番号 58829-72-4
分子量 524.51
分子式 C₂₅H₃₂O₁₂
SMILES

OC1=C(C(C)=O)C(C)=CC2=CC=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]4[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C)O4)O3)O)=C21
Structure Classification
- Phenols
- Monophenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Alebachew Y, et al. In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents. Malar J. 2021;20(1):3. Published 2021 Jan 1. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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