Dipeptide 2
Based on 1 Customer Validation
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC50 of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.12%
- CAS 番号: 24587-37-9
- 分子式: C16H21N3O3
- 分子量:303.36
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
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eNOS |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | EC50 |
0.04 mM
Compound: 79
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Activation of human PEPT1 expressed in MDCK cells
Activation of human PEPT1 expressed in MDCK cells
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[PMID: 16759105] |
| MDCK | IC50 |
0.1 mM
Compound: 79
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
Dipeptide 2 potently inhibits purified ACE with an IC50 of 10.50 ± 0.97 μM[2].
Dipeptide 2 (12.5-50 μM; 24 h) is non-toxic to HUVECs[2].
Dipeptide 2 (12.5-50 μM; 4 h) reduces intracellular calcium concentration in Ang I-induced HUVECs, promoting vascular smooth muscle relaxation[2].
Dipeptide 2 (12.5-50 μM; 4 h) promotes NO production in Ang I-induced HUVECs, with a 12.9% increase at 50 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ang I-induced human umbilical vein endothelial cells (HUVECs)
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Concentration:12.5-50 μM
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Incubation Time:4 h
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Result:Significantly inhibited ET-1 protein expression and stimulated eNOS phosphorylation compared to the Ang I-only group.
Caused a 60.4% reduction in ET-1 and a 92.9% increase in p-eNOS protein expression in the 50 μM group.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SHRs (male, 8 weeks old, 220 ± 20 g, spontaneously hypertensive model)[2]
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Dosage:10 mg/kg; 40 mg/kg
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Administration:p.o.; once daily; 12 days
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Result:Significantly suppressed diastolic blood pressure (DBP) in SHRs between days 8 and 12, with DBP reductions ranging from 3 to 27 mmHg.
Produced a maximum DBP reduction of 27 mmHg on day 12 at 40 mg/kg.
Reduced systolic blood pressure (SBP) by 32 mmHg on day 12.
化学情報
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CAS 番号 24587-37-9
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性状 Solid
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分子量 303.36
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分子式 C16H21N3O3
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Color White to off-white
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別名
N-Valyltryptophan; Val-Trp
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配列
Val-Trp
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シーケンスの短縮
VW
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 12.5 mg/mL (41.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2964 mL | 16.4821 mL | 32.9641 mL | 82.4103 mL |
| 5 mM | 0.6593 mL | 3.2964 mL | 6.5928 mL | 16.4821 mL | |
| 10 mM | 0.3296 mL | 1.6482 mL | 3.2964 mL | 8.2410 mL | |
| 15 mM | 0.2198 mL | 1.0988 mL | 2.1976 mL | 5.4940 mL | |
| 20 mM | 0.1648 mL | 0.8241 mL | 1.6482 mL | 4.1205 mL | |
| 25 mM | 0.1319 mL | 0.6593 mL | 1.3186 mL | 3.2964 mL | |
| 30 mM | 0.1099 mL | 0.5494 mL | 1.0988 mL | 2.7470 mL | |
| 40 mM | 0.0824 mL | 0.4121 mL | 0.8241 mL | 2.0603 mL |
Dipeptide 2 関連分類
HY-118060 関連分類
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